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Randomized Controlled Trial
. 2020 Dec;25(4):344-349.
doi: 10.1111/jns.12411. Epub 2020 Sep 18.

The Brighton Collaboration case definition: Comparison in a retrospective and prospective cohort of children with Guillain-Barré syndrome

Rudolf Korinthenberg  1   2 , James J Sejvar  3
Affiliations
Randomized Controlled Trial

The Brighton Collaboration case definition: Comparison in a retrospective and prospective cohort of children with Guillain-Barré syndrome

Rudolf Korinthenberg et al. J Peripher Nerv Syst. 2020 Dec.

Abstract

Guillain-Barré syndrome (GBS) is an immune-mediated polyradiculoneuropathy frequently preceded by an infection with Campylobacter jejuni or nonspecific infections, and rarely by a vaccination. Due to a lack of a pathognomonic finding or biomarker, its diagnosis is based on a typical constellation of clinical and paraclinical symptoms and findings. The Brighton Collaboration GBS Working Group published in 2011 GBS case definitions and guidelines for diagnosis to improve the registration of GBS cases occurring in conjunction with vaccination programs worldwide. We applied these criteria to two historical studies on GBS in children and adolescents performed retrospectively from 1989 to 1994 and prospectively from 1998 to 2002. The clinical criteria were met in 91% of the retrospective and all of the prospective cases. CSF investigations were conducted in all patients and revealed cytoalbuminologic dissociation in 80% of the retrospective and 75% of the prospective cohort. Nerve conduction studies were performed in 61% and 69% of the cohorts, respectively, and were pathological in 92% each. The Brighton criteria are well suited to capture GBS in retro- and prospective studies. However, because they are designed to diagnose classical symmetric and ascending GBS and Fisher syndrome, very rare topographical variants of GBS such as the pharyngo-cervico-brachial variant and others could be missed.

Keywords: GBS; GBS variants; Guillain-Barré syndrome; adolescents; children.

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References

REFERENCES

    1. Sejvar JJ, Kohl KS, Gidudu J, et al.; Brighton Collaboration GBS Working GroupGuillain-Barre syndrome and Fisher syndrome: case definitions and guidelines for collection, analysis, and presentation of immunization safety data. Vaccine. 2011;29(3):599-612. https://doi.org/10.1016/j.vaccine.2010.06.003.
    1. Asbury AK, Cornblath DR. Assessment of current diagnostic criteria for Guillain-Barré syndrome. Ann Neurol. 1990;27(suppl):S21-S24.
    1. Van der Meche FG, van Doorn PA, Meulstee J, Jennekens FG. Diagnostic and classification criteria for the Guillain-Barre syndrome. Eur Neurol. 2001;45(3):133-139. https://doi.org/10.1159/000052111.
    1. Hughes RA, Cornblath DR. Guillain-Barre syndrome. Lancet. 2005;366(9497):1653-1666. https://doi.org/10.1016/S0140-6736(05)67665-9.
    1. Choe YJ, Cho H, Bae G, Lee J. Guillain-Barre syndrome following receipt of influenza A (H1N1) 2009 monovalent vaccine in Korea with an emphasis on Brighton Collaboration case definition. Vaccine. 2011;29(11):2066-2070. https://doi.org/10.1016/j.vaccine.2011.01.007.

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