Personalized medicine for allergy treatment: Allergen immunotherapy still a unique and unmatched model

Cristoforo Incorvaia¹, Mona Al-Ahmad^{2

3}, Ignacio J Ansotegui⁴, Stefania Arasi⁵, Claus Bachert^{6

7

8}, Catherine Bos⁹, Jean Bousquet¹⁰, Andrzéj Bozek¹¹, Davide Caimmi¹², Moises A Calderón¹³, Thomas Casale¹⁴, Adnan Custovic¹⁵, Frédéric De Blay¹⁶, Pascal Demoly^{12

17}, Philippe Devillier¹⁸, Alain Didier¹⁹, Alessandro Fiocchi⁵, Adam T Fox²⁰, Philippe Gevaert⁶, Maximiliano Gomez²¹, Enrico Heffler^{22

23}, Natalia Ilina²⁴, Carla Irani²⁵, Marek Jutel²⁶, Efstrathios Karagiannis⁹, Ludger Klimek²⁷, Piotr Kuna²⁸, Robin O'Hehir²⁹, Oxana Kurbacheva³⁰, Paolo M Matricardi³¹, Mario Morais-Almeida^{32

33}, Ralph Mosges^{34

35}, Natalija Novak³⁶, Yoshitaka Okamoto³⁷, Petr Panzner³⁸, Nikolaos G Papadopoulos^{39

40}, Hae-Sim Park⁴¹, Giovanni Passalacqua⁴², Ruby Pawankar⁴³, Oliver Pfaar⁴⁴, Peter Schmid-Grendelmeier⁴⁵, Silvia Scurati⁹, Miguel Tortajada-Girbés^{46

47

48}, Carmen Vidal⁴⁹, J Christian Virchow⁵⁰, Ulrich Wahn³¹, Margitta Worm³¹, Petra Zieglmayer⁵¹, Giorgio W Canonica^{22

23}

Affiliations

¹ Cardiac/Pulmonary Rehabilitation, ASST Pini/CTO, Milan, Italy.
² Microbiology Department, Faculty of Medicine, Kuwait University, Kuwait.
³ Drug Allergy Unit, Department of Allergy, Al-Rashed Allergy Center, Kuwait.
⁴ Hospital Quirónsalud Bizkaia, Bilbao, Spain.
⁵ Department of Allergy, Bambino Gesu' Childrens' Hospital IRCCS, Rome, Italy.
⁶ Upper Airways Research Laboratory, ENT Dept, Ghent University Hospital, Ghent, Belgium.
⁷ Karolinska Institutet, Stockholm, Sweden.
⁸ Department of ENT Diseases, Karolinska University Hospital, Stockholm, Sweden.
⁹ Stallergenes Greer Medical Affairs Department, Antony, France.
¹⁰ University Hospital Montpellier, France - MACVIA-France, Montpellier, France.
¹¹ Clinical Department of Internal Disease, Dermatology and Allergology, Medical University of Silesia, Katowice, Poland.
¹² Department of Pulmonology and Addictology, Arnaud de Villeneuve Hospital, Montpellier University, Montpellier, France.
¹³ Imperial College London - National Heart and Lung Institute, Royal Brompton Hospital NHS, London, UK.
¹⁴ Division of Allergy/Immunology, University of South Florida, Tampa, FL, USA.
¹⁵ Centre for Respiratory Medicine and Allergy, Institute of Inflammation and Repair, University of Manchester and University Hospital of South Manchester, Manchester, UK.
¹⁶ Allergy Division, Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France.
¹⁷ Sorbonne Université, UMR-S 1136 INSERM, IPLESP, EPAR Team, Paris, France.
¹⁸ Laboratoire de Recherche en Pharmacologie Respiratoire, Pôle des Maladies des Voies Respiratoires, Hôpital Foch, Université Paris-Saclay, Suresnes, France.
¹⁹ Respiratory Disease Dept, Larrey Hospital, University Hospital of Toulouse, Paul Sabatier University, Toulouse, France.
²⁰ Department of Paediatric Allergy, Guy's & St Thomas' Hospitals NHS Foundation Trust, London, UK.
²¹ Allergy & Asthma Unit, Hospital San Bernardo Salta, Salta, Argentina.
²² Personalized Medicine, Asthma & Allergy - Humanitas Clinical and Research Center IRCCS, Rozzano, Italy.
²³ Department of Biomedical Science, Humanitas University, Pieve Emanuele, Italy.
²⁴ Federal Institute of Immunology of Russia, Moscow, Russia.
²⁵ Department of Internal Medicine and Clinical Immunology, Faculty of Medicine, Hotel Dieu de France Hospital, Saint Joseph University, Beirut, Lebanon.
²⁶ Department of Clinical Immunology, Wrocław Medical University, Wrocław, Poland.
²⁷ Center for Rhinology and Allergology, Wiesbaden, Germany.
²⁸ Division of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, Medical University of Lodz, Lodz, Poland.
²⁹ Alfred Hospital and Monash University, Melbourne, Australia.
³⁰ National Research Center - Institute of Immunology Federal Medical-Biological Agency of Russia, Moscow, Russia.
³¹ Department of Pediatric Pulmonology, Immunology and Intensive Care Medicine, Charité - University Medicine Berlin, Berlin, Germany.
³² Immunoallergy Department of CUF-Descobertas Hospital, Lisbon, Portugal.
³³ CUF-Infante Santo Hospital, Lisbon, Portugal.
³⁴ Faculty of Medicine, Institute of Medical Statistics and Computational Biology, University of Cologne, Cologne, Germany.
³⁵ CRI - Clinical Research International Ltd., Cologne, Germany.
³⁶ Department of Dermatology and Allergy, University Hospital Bonn, Bonn, Germany.
³⁷ Department of Otorhinolaryngology, Chiba University Hospital, Chiba, Japan.
³⁸ Department of Immunology and Allergology, Faculty of Medicine in Pilsen, Charles University in Prague, Pilsen, Czech Republic.
³⁹ Division of Infection, Immunity & Respiratory Medicine, Royal Manchester Children's Hospital, University of Manchester, Manchester, UK.
⁴⁰ Allergy Department, 2nd Pediatric Clinic, Athens General Children's Hospital "P&A Kyriakou", University of Athens, Athens, Greece.
⁴¹ Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, South Korea.
⁴² Allergy and Respiratory Diseases, Ospedale Policlino San Martino - University of Genoa, Genoa, Italy.
⁴³ Department of Pediatrics, Nippon Medical School, Tokyo, Japan.
⁴⁴ Department of Otorhinolaryngology, Head and Neck Surgery, Section of Rhinology and Allergy, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany.
⁴⁵ Department of Dermatology, University Hospital of Zürich, Zürich, Switzerland.
⁴⁶ Pediatric Pulmonology and Allergy Unit, Department of Pediatrics, Dr. Peset University Hospital, Valencia, Spain.
⁴⁷ Department of Pediatrics, Obstetrics and Gynecology, University of Valencia, Valencia, Spain.
⁴⁸ IVI Foundation, Valencia, Spain.
⁴⁹ Allergy Service, Complejo Hospitalario Universitario de Santiago, Santiago de Compostela, Spain.
⁵⁰ Department of Pneumology/Intensive Care Medicine, University of Rostock, Rostock, Germany.
⁵¹ Vienna Challenge Chamber, Vienna, Austria.

PMID: 32869882
DOI: 10.1111/all.14575

Review

Personalized medicine for allergy treatment: Allergen immunotherapy still a unique and unmatched model

Cristoforo Incorvaia et al. Allergy. 2021 Apr.

. 2021 Apr;76(4):1041-1052.

doi: 10.1111/all.14575. Epub 2020 Oct 19.

Authors

Affiliations

¹ Cardiac/Pulmonary Rehabilitation, ASST Pini/CTO, Milan, Italy.
² Microbiology Department, Faculty of Medicine, Kuwait University, Kuwait.
³ Drug Allergy Unit, Department of Allergy, Al-Rashed Allergy Center, Kuwait.
⁴ Hospital Quirónsalud Bizkaia, Bilbao, Spain.
⁵ Department of Allergy, Bambino Gesu' Childrens' Hospital IRCCS, Rome, Italy.
⁶ Upper Airways Research Laboratory, ENT Dept, Ghent University Hospital, Ghent, Belgium.
⁷ Karolinska Institutet, Stockholm, Sweden.
⁸ Department of ENT Diseases, Karolinska University Hospital, Stockholm, Sweden.
⁹ Stallergenes Greer Medical Affairs Department, Antony, France.
¹⁰ University Hospital Montpellier, France - MACVIA-France, Montpellier, France.
¹¹ Clinical Department of Internal Disease, Dermatology and Allergology, Medical University of Silesia, Katowice, Poland.
¹² Department of Pulmonology and Addictology, Arnaud de Villeneuve Hospital, Montpellier University, Montpellier, France.
¹³ Imperial College London - National Heart and Lung Institute, Royal Brompton Hospital NHS, London, UK.
¹⁴ Division of Allergy/Immunology, University of South Florida, Tampa, FL, USA.
¹⁵ Centre for Respiratory Medicine and Allergy, Institute of Inflammation and Repair, University of Manchester and University Hospital of South Manchester, Manchester, UK.
¹⁶ Allergy Division, Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France.
¹⁷ Sorbonne Université, UMR-S 1136 INSERM, IPLESP, EPAR Team, Paris, France.
¹⁸ Laboratoire de Recherche en Pharmacologie Respiratoire, Pôle des Maladies des Voies Respiratoires, Hôpital Foch, Université Paris-Saclay, Suresnes, France.
¹⁹ Respiratory Disease Dept, Larrey Hospital, University Hospital of Toulouse, Paul Sabatier University, Toulouse, France.
²⁰ Department of Paediatric Allergy, Guy's & St Thomas' Hospitals NHS Foundation Trust, London, UK.
²¹ Allergy & Asthma Unit, Hospital San Bernardo Salta, Salta, Argentina.
²² Personalized Medicine, Asthma & Allergy - Humanitas Clinical and Research Center IRCCS, Rozzano, Italy.
²³ Department of Biomedical Science, Humanitas University, Pieve Emanuele, Italy.
²⁴ Federal Institute of Immunology of Russia, Moscow, Russia.
²⁵ Department of Internal Medicine and Clinical Immunology, Faculty of Medicine, Hotel Dieu de France Hospital, Saint Joseph University, Beirut, Lebanon.
²⁶ Department of Clinical Immunology, Wrocław Medical University, Wrocław, Poland.
²⁷ Center for Rhinology and Allergology, Wiesbaden, Germany.
²⁸ Division of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, Medical University of Lodz, Lodz, Poland.
²⁹ Alfred Hospital and Monash University, Melbourne, Australia.
³⁰ National Research Center - Institute of Immunology Federal Medical-Biological Agency of Russia, Moscow, Russia.
³¹ Department of Pediatric Pulmonology, Immunology and Intensive Care Medicine, Charité - University Medicine Berlin, Berlin, Germany.
³² Immunoallergy Department of CUF-Descobertas Hospital, Lisbon, Portugal.
³³ CUF-Infante Santo Hospital, Lisbon, Portugal.
³⁴ Faculty of Medicine, Institute of Medical Statistics and Computational Biology, University of Cologne, Cologne, Germany.
³⁵ CRI - Clinical Research International Ltd., Cologne, Germany.
³⁶ Department of Dermatology and Allergy, University Hospital Bonn, Bonn, Germany.
³⁷ Department of Otorhinolaryngology, Chiba University Hospital, Chiba, Japan.
³⁸ Department of Immunology and Allergology, Faculty of Medicine in Pilsen, Charles University in Prague, Pilsen, Czech Republic.
³⁹ Division of Infection, Immunity & Respiratory Medicine, Royal Manchester Children's Hospital, University of Manchester, Manchester, UK.
⁴⁰ Allergy Department, 2nd Pediatric Clinic, Athens General Children's Hospital "P&A Kyriakou", University of Athens, Athens, Greece.
⁴¹ Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, South Korea.
⁴² Allergy and Respiratory Diseases, Ospedale Policlino San Martino - University of Genoa, Genoa, Italy.
⁴³ Department of Pediatrics, Nippon Medical School, Tokyo, Japan.
⁴⁴ Department of Otorhinolaryngology, Head and Neck Surgery, Section of Rhinology and Allergy, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany.
⁴⁵ Department of Dermatology, University Hospital of Zürich, Zürich, Switzerland.
⁴⁶ Pediatric Pulmonology and Allergy Unit, Department of Pediatrics, Dr. Peset University Hospital, Valencia, Spain.
⁴⁷ Department of Pediatrics, Obstetrics and Gynecology, University of Valencia, Valencia, Spain.
⁴⁸ IVI Foundation, Valencia, Spain.
⁴⁹ Allergy Service, Complejo Hospitalario Universitario de Santiago, Santiago de Compostela, Spain.
⁵⁰ Department of Pneumology/Intensive Care Medicine, University of Rostock, Rostock, Germany.
⁵¹ Vienna Challenge Chamber, Vienna, Austria.

PMID: 32869882
DOI: 10.1111/all.14575

Abstract

The introduction of personalized medicine (PM) has been a milestone in the history of medical therapy, because it has revolutionized the previous approach of treating the disease with that of treating the patient. It is known today that diseases can occur in different genetic variants, making specific treatments of proven efficacy necessary for a given endotype. Allergic diseases are particularly suitable for PM, because they meet the therapeutic success requirements, including a known molecular mechanism of the disease, a diagnostic tool for such disease, and a treatment blocking the mechanism. The stakes of PM in allergic patients are molecular diagnostics, to detect specific IgE to single-allergen molecules and to distinguish the causative molecules from those merely cross-reactive, pursuit of patient's treatable traits addressing genetic, phenotypic, and psychosocial features, and omics, such as proteomics, epi-genomics, metabolomics, and breathomics, to forecast patient's responsiveness to therapies, to detect biomarker and mediators, and to verify the disease control. This new approach has already improved the precision of allergy diagnosis and is likely to significantly increase, through the higher performance achieved with the personalized treatment, the effectiveness of allergen immunotherapy by enhancing its already known and unique characteristics of treatment that acts on the causes.

Keywords: allergen immunotherapy; molecular diagnosis; omics; personalized medicine; treatable traits.

PubMed Disclaimer

References

REFERENCES

1. Jones AW. Early drug discovery and the rise of pharmaceutical chemistry. Drug Test Anal. 2011;3(6):337-344.
1. Mahner M, Kary M. What exactly are genomes, genotypes and phenotypes? And what about phenomes? J Theoretical Biol. 1997;186:55-63.
1. Febbo PG, Ginsburg GS. Personalized diagnostic and therapeutic strategies in oncology. Per Med. 2005;2(2):97-110.
1. Collins FS, Varmus H. A new initiative on precision medicine. N Engl J Med. 2015;372(9):793-795.
1. Busse WW. Biological treatments for severe asthma: a major advance in asthma care. Allergol Int. 2019;68(2):158-166.

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions

LinkOut - more resources

Full Text Sources
- Ovid Technologies, Inc.
- Wiley
Medical
- MedlinePlus Health Information

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Personalized medicine for allergy treatment: Allergen immunotherapy still a unique and unmatched model

Affiliations

Personalized medicine for allergy treatment: Allergen immunotherapy still a unique and unmatched model

Authors

Affiliations

Abstract

References

REFERENCES

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Medical