Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Nov;30(11):1228-1238.
doi: 10.1002/hipo.23256. Epub 2020 Sep 1.

Selective neuromodulation and mutual inhibition within the CA3-CA2 system can prioritize sequences for replay

Tristan M Stöber  1   2   3 , Andrew B Lehr  1   2   4 , Torkel Hafting  2   5 , Arvind Kumar  6 , Marianne Fyhn  2   7
Affiliations
Review

Selective neuromodulation and mutual inhibition within the CA3-CA2 system can prioritize sequences for replay

Tristan M Stöber et al. Hippocampus. 2020 Nov.

Abstract

To make optimal use of previous experiences, important neural activity sequences must be prioritized during hippocampal replay. Integrating insights about the interplay between CA3 and CA2, we propose a conceptual framework that allows the two regions to control which sequences are reactivated. We suggest that neuromodulatory-gated plasticity and mutual inhibition enable discrete assembly sequences in both regions to support each other while suppressing competing sequences. This perspective provides a coherent interpretation for a variety of seemingly disconnected functional properties of CA2 and paves the way for a more general understanding of CA2.

Keywords: CA2; CA3; consolidation; hippocampus; sequence prioritization.

PubMed Disclaimer

References

REFERENCES

    1. Alexander, G. M., Brown, L. Y., Farris, S., Lustberg, D., Pantazis, C., Gloss, B., … Dudek, S. M. (2018). CA2 neuronal activity controls hippocampal low gamma and ripple oscillations. eLife, 7, e38052.
    1. Alexander, G. M., Farris, S., Pirone, J. R., Zheng, C., Colgin, L. L., & Dudek, S. M. (2016). Social and novel contexts modify hippocampal CA2 representations of space. Nature Communications, 7(1), 1-14.
    1. Bartesaghi, R., & Gessi, T. (2004). Parallel activation of field CA2 and dentate gyrus by synaptically elicited perforant path volleys. Hippocampus, 14(8), 948-963.
    1. Bazelot, M., Dinocourt, C., Cohen, I., & Miles, R. (2010). Unitary inhibitory field potentials in the CA3 region of rat hippocampus. The Journal of Physiology, 588(12), 2077-2090.
    1. Benoy, A., Dasgupta, A., & Sajikumar, S. (2018). Hippocampal area CA2: An emerging modulatory gateway in the hippocampal circuit. Experimental Brain Research, 236(4), 919-931.

Publication types

MeSH terms

LinkOut - more resources