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. 2020 Aug:34 Suppl 5:43-48.
doi: 10.1111/jdv.16641.

Cutaneous sensitivity modulation by Aquaphilus dolomiae extract-G3 on in vitro models of neuro-inflammation

F Lestienne  1 , C Viodé  1 , I Ceruti  1 , S Carrere  1 , S Bessou-Touya  1 , H Duplan  1 , N Castex-Rizzi  1
Affiliations

Cutaneous sensitivity modulation by Aquaphilus dolomiae extract-G3 on in vitro models of neuro-inflammation

F Lestienne et al. J Eur Acad Dermatol Venereol. 2020 Aug.

Abstract

Background: Inflammatory skin disorders, including atopic dermatitis (AD), associated pruritus and sensitive skin, have a complex multifactorial pathogenesis including neurogenic inflammation involving the release in blood and skin of neurotransmitters such as substance P (SP).

Aims and methods: In vitro models evaluated the effect of the original biological extract of Aquaphilus dolomiae extract-G3 (ADE-G3) on cutaneous neurogenic inflammation.

Results: ADE-G3 significantly inhibited SP-stimulated release of IL-1β and TNF-α from normal human epidermal keratinocytes; significantly and dose-dependently inhibited SP-stimulated activation of human mast cells; significantly inhibited veratridine-stimulated release of SP from human sensory neurons; modulated expression of genes involved in lipid synthesis, innate immunity, corneocyte scaffolding and epidermal differentiation in a histamine-sensitized reconstructed human epidermis model; and, when applied topically to ex vivo human explants, inhibited IL-8 and histamine release.

Conclusions: Topically applied ADE-G3, once formulated, may improve neuro-inflammation in patients with inflammatory skin disorders.

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References

    1. Yosipovitch G, Bernhard JD. Clinical practice. Chronic pruritus. N Engl J Med 2013; 368: 1625-1634.
    1. Tominaga M, Takamori K. An update on peripheral mechanisms and treatments of itch. Biol Pharm Bull 2013; 36: 1241-1247.
    1. Peng W, Novak N. Pathogenesis of atopic dermatitis. Clin Exp Allergy 2015; 45: 566-574.
    1. Mollanazar NK, Smith PK, Yosipovitch G. Mediators of chronic pruritus in atopic dermatitis: getting the itch out? Clin Rev Allergy Immunol 2016; 51: 263-292.
    1. Guttman-Yassky E, Waldman A, Ahluwalia J, Ong PY, Eichenfield LF. Atopic dermatitis: pathogenesis. Semin Cutan Med Surg 2017; 36: 100-103.

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