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Case Reports
. 2020 Sep-Oct;34(5):2217-2223.
doi: 10.21873/invivo.12032.

Nuchal-type Fibroma: Single-Center Experience and Systematic Literature Review

Ioannis D Kostakis #  1 , Themistoklis Feretis #  2 , Christos Damaskos #  3   4 , Nikolaos Garmpis  4   5 , George Liapis  6 , Ioannis Pateras  6 , Anna Garmpi  7 , Vasiliki E Georgakopoulou  8   9 , Efstathios A Antoniou  4   5
Affiliations
Case Reports

Nuchal-type Fibroma: Single-Center Experience and Systematic Literature Review

Ioannis D Kostakis et al. In Vivo. 2020 Sep-Oct.

Abstract

Background: Nuchal-type fibroma is a rare benign tumor arising from the connective tissue. Our aim was to present our experience via two cases of this tumor and a comprehensive review of the literature.

Patients and methods: We report a case of a 23-year-old female with a mass located in the posterior neck and the upper back and a case of a 50-year-old male with a mass located in the posterior neck, which were proved to be nuchal-type fibromas in the histopathological examination. We also searched the PubMed/Medline database for published cases of nuchal-type fibromas.

Results and discussion: Nuchal-type fibroma is a rare benign tumor arising from the connective tissue, usually in the posterior neck, which affects different ages, with most patients being male. It is a poorly circumscribed tumor consisting of hypocellular, thick, dense and haphazardly arranged collagen bundles with entrapped adipocytes, nerve fibers and muscle fascicles and a few scattered spindle cells, which are CD34 positive. Its excision is curative, and the recurrence risk is generally low. However, patients with Gardner's syndrome may experience recurrence more frequently.

Conclusion: Nuchal-type fibroma should be included in the differential diagnosis of subcutaneous, soft-tissue masses, especially when these involve the posterior neck.

Keywords: CD34; Nuchal; fibroma; review; tumor.

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Conflict of interest statement

All the Authors declare that there are no conflicts of interest regarding this study.

Figures

Figure 1
Figure 1. Magnetic resonance imaging (MRI) findings. A: MRI scan (T1 weighted sequence) showing two tumors with high signal intensity located in the posterior neck and the upper back; B: MRI scan (T1 weighted sequence) showing heterogeneous contrast enhancement of the larger tumor and homogeneous contrast enhancement of the smaller tumor.
Figure 2
Figure 2. Macroscopic view of the surgical specimen.
Figure 3
Figure 3. Microscopic view of the surgical specimen. A: Thick, haphazardly arranged collagen fibers with entrapped adipocytes and a few spindle cells (hematoxylin and eosin stain, 100× original magnification). B: Spindle cells stained positive for CD34 (100× original magnification). C: Microscopic view of the surgical specimen. Thick, haphazardly arranged collagen fibers with entrapped adipocytes and a few spindle cells (hematoxylin and eosin stain, 200× original magnification).
Figure 4
Figure 4. Macroscopic view of the surgical specimen.
See this image and copyright information in PMC

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