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. 2020 Aug 14;99(33):e21680.
doi: 10.1097/MD.0000000000021680.

Retinal nerve fiber layer changes in migraine: A protocol for systematic review and meta-analysis

XiaoGuang Lin  1 , ZhongQuan Yi  2 , XueLing Zhang  1 , QinQin Liu  1 , RuYuan Cai  3 , ChaoChun Chen  3 , HongJie Zhang  3 , PanWen Zhao  2 , PingLei Pan  2   4
Affiliations

Retinal nerve fiber layer changes in migraine: A protocol for systematic review and meta-analysis

XiaoGuang Lin et al. Medicine (Baltimore). .

Abstract

Background: Migraine is a common neurological disease, which seriously affects the quality of life and daily activities of patients. Although migraine is a transient phenomenon of cerebral vasoconstriction, it is well documented that recurrent attacks of migraine may lead to abnormalities in retinal structure. Optical coherence tomography (OCT) is a sensitive method to detect subtle damage in retinal nerve fiber layer (RNFL). There have been many studies investigating the difference in RNFL thickness with optical coherence tomography (OCT) between migraine patients and healthy controls. However, the results were not consistent. Our purpose is to perform a meta-analysis to investigate RNFL alterations in migraine.

Methods: We will search PubMed, Embase, Web of science for studies assessing the differences in RNFL measured by OCT between patients with migraine and healthy controls. Case-control studies published in English will be included. Two reviewers will independently screen eligible articles, extract data, and assess quality. This meta-analysis will synthesize selected research data and compare the difference in RNFL thickness between patients with migraine and healthy controls. We will use Stata 15 in this meta-analysis. I statistics will be used to assess heterogeneity. If I ≤ 50%, the data are synthesized will use a fixed effect model. Otherwise, a random effect model will be performed. Publication bias will be determined by the Egger test. The methodological quality of all included studies will be evaluated by the Newcastle-Ottawa Scale (NOS). We will perform subgroup analysis, sensitivity analysis, and meta-regression analysis to test the robustness of the results.

Results: We will obtain quantitative results regarding the difference in RNFL thickness between migraine patients and healthy controls. The results will be published in a peer-reviewed journal.

Conclusions: The results of this study provide a high-quality synthesis of existing evidence and provide a basis for assessing the effect of migraine on the thickness of RNFL.

Registration number: INPLASY 202060033.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Figure 1
Figure 1
The PRISMA flow diagram of study selection process.
See this image and copyright information in PMC

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References

    1. Barnett R. Migraine. Lancet 2019;394:1897. - PubMed
    1. Buse DC, Silberstein SD, Manack AN, et al. Psychiatric comorbidities of episodic and chronic migraine. J Neurol 2013;260:1960–9. - PubMed
    1. Wang SJ, Chen PK, Fuh JL. Comorbidities of migraine. Front Neurol 2010;1:16. - PMC - PubMed
    1. Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet 2017;390:1211–59. - PMC - PubMed
    1. Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet 2016;388:1545–602. - PMC - PubMed

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