Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Aug 28;17(17):6278.
doi: 10.3390/ijerph17176278.

The Characteristic of Virulence, Biofilm and Antibiotic Resistance of Klebsiella pneumoniae

Guoying Wang  1 , Guo Zhao  1 , Xiaoyu Chao  1 , Longxiang Xie  1 , Hongju Wang  1
Affiliations
Review

The Characteristic of Virulence, Biofilm and Antibiotic Resistance of Klebsiella pneumoniae

Guoying Wang et al. Int J Environ Res Public Health. .

Abstract

Klebsiella pneumoniae is an important gram-negative opportunistic pathogen that causes a variety of infectious diseases, including urinary tract infections, bacteremia, pneumonia, and liver abscesses. With the emergence of multidrug-resistant (MDR) and hypervirulent K. pneumoniae (hvKP) strains, the rapid spread of these clinical strains in geography is particularly worrying. However, the detailed mechanisms of virulence and antibiotic resistance in K. pneumoniae are still not very clear. Therefore, studying and elucidating the pathogenic mechanisms and drug resistance mechanism of K. pneumoniae infection are important parts of current medical research. In this paper, we systematically summarized the virulence, biofilm, and antibiotic tolerance mechanisms of K. pneumoniae, and explored the application of whole genome sequencing and global proteomics, which will provide new clues for clinical treatment of K. pneumoniae.

Keywords: K. pneumoniae; biofilm; multidrug-resistant; pathogenicity.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Schematic presentation of Klebsiella pneumoniae virulence factors, and biofilm homeostasis.
See this image and copyright information in PMC

References

    1. Podschun R., Ullmann U. Klebsiella spp. as nosocomial pathogens: Epidemiology, taxonomy, typing methods, and pathogenicity factors. Clin. Microbiol. Rev. 1998;11:589–603. doi: 10.1128/CMR.11.4.589. - DOI - PMC - PubMed
    1. Holt K.E., Wertheim H., Zadoks R.N., Baker S., Whitehouse C.A., Dance D., Jenney A., Connor T.R., Hsu L.Y., Severin J., et al. Genomic analysis of diversity, population structure, virulence, and antimicrobial resistance in Klebsiella pneumoniae, an urgent threat to public health. Proc. Natl. Acad. Sci. USA. 2015;112:E3574–E3581. doi: 10.1073/pnas.1501049112. - DOI - PMC - PubMed
    1. Chew K.L., Lin R.T.P., Teo J.W.P. Klebsiella pneumoniae in Singapore: Hypervirulent Infections and the Carbapenemase Threat. Front. Cell. Infect. Microbiol. 2017;7:515. doi: 10.3389/fcimb.2017.00515. - DOI - PMC - PubMed
    1. Zhang Y., Yao Z., Zhan S., Yang Z., Wei D., Zhang J., Li J., Kyaw M.H. Disease burden of intensive care unit-acquired pneumonia in China: A systematic review and meta-analysis. Int. J. Infect. Dis. 2014;29:84–90. doi: 10.1016/j.ijid.2014.05.030. - DOI - PubMed
    1. Zhang Y., Wang Q., Yin Y., Chen H., Jin L., Gu B., Xie L., Yang C., Ma X., Li H., et al. Epidemiology of Carbapenem-Resistant Enterobacteriaceae Infections: Report from the China CRE Network. Antimicrob. Agents Chemother. 2018;62 doi: 10.1128/AAC.01882-17. - DOI - PMC - PubMed

Publication types

MeSH terms