Hypothyroidism-induced Acute Kidney Injury and Hyponatremia

Abstract

Thyroid hormones affect every organ system in the body including renal development and physiology, and electrolyte and water homeostasis. These effects happen as a consequence of the combination of direct effects of thyroid hormones on renal tubules and hemodynamic effects of thyroid hormones. As a consequence, both hypothyroidism and hyperthyroidism significantly affect renal function. This case describes a patient with hypothyroidism-related acute kidney injury without rhabdomyolysis, and no additional precipitating factor. While there are many case reports describing hypothyroidism-related rhabdomyolysis leading to acute kidney injury, there are only a handful of case reports on hypothyroidism-related acute kidney injury without rhabdomyolysis.

Keywords: acute kidney injury; hyponatremia; hypothyroidism; rhabdomyolysis.