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Comment
. 2020 Sep;10(9):1255-1257.
doi: 10.1158/2159-8290.CD-20-0949.

The Aged Microenvironment of Melanoma Feeds Escape from Targeted Therapy

Emily D Montal  1 , Richard M White  2
Affiliations
Comment

The Aged Microenvironment of Melanoma Feeds Escape from Targeted Therapy

Emily D Montal et al. Cancer Discov. 2020 Sep.

Abstract

Alicea and colleagues demonstrate that aged fibroblasts secrete lipids into the tumor microenvironment, allowing for nutrient exchange with melanoma cells. This supportive function of fibroblasts results in increased resistance to BRAF/MEKi therapy in the context of an aged microenvironment, providing crucial mechanistic insight into age-related drug resistance.See related article by Alicea et al., p. 1282.

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References

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