Increased mortality of COVID-19 infected diabetes patients: role of furin proteases

doi:10.1038/s41366-020-00670-9

. 2020 Dec;44(12):2486-2488.

doi: 10.1038/s41366-020-00670-9. Epub 2020 Sep 1.

Increased mortality of COVID-19 infected diabetes patients: role of furin proteases

Senthil Kumar Ganesan^{1

2}, Purushothaman Venkatratnam³, Jaideep Mahendra⁴, Nalini Devarajan⁵

Affiliations

¹ Laboratory of Functional Genomics, Structural Biology & Bioinformatics Division, CSIR-Indian Institute of Chemical Biology, TRUE Campus, CN Block-6, Sector V, Salt Lake, Kolkata, 700091, India. skumar@iicb.res.in.
² Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India. skumar@iicb.res.in.
³ Meenakshi Ammal Dental College and Hospital, Maduravoyal, Chennai, 600095, Tamil Nadu, India.
⁴ Department of Periodontology, Meenakshi Ammal Dental College and Hospital, Maduravoyal, Chennai, 600095, Tamil Nadu, India.
⁵ Central Research Laboratory, Meenakshi Ammal Dental College, Meenakshi Academy of Higher Education and Research, Maduravoyal, Chennai, Tamil Nadu, India. nalinikrishu@gmail.com.

PMID: 32873908
PMCID: PMC7461147
DOI: 10.1038/s41366-020-00670-9

Increased mortality of COVID-19 infected diabetes patients: role of furin proteases

Senthil Kumar Ganesan et al. Int J Obes (Lond). 2020 Dec.

. 2020 Dec;44(12):2486-2488.

doi: 10.1038/s41366-020-00670-9. Epub 2020 Sep 1.

Authors

Senthil Kumar Ganesan^{1

2}, Purushothaman Venkatratnam³, Jaideep Mahendra⁴, Nalini Devarajan⁵

Affiliations

¹ Laboratory of Functional Genomics, Structural Biology & Bioinformatics Division, CSIR-Indian Institute of Chemical Biology, TRUE Campus, CN Block-6, Sector V, Salt Lake, Kolkata, 700091, India. skumar@iicb.res.in.
² Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India. skumar@iicb.res.in.
³ Meenakshi Ammal Dental College and Hospital, Maduravoyal, Chennai, 600095, Tamil Nadu, India.
⁴ Department of Periodontology, Meenakshi Ammal Dental College and Hospital, Maduravoyal, Chennai, 600095, Tamil Nadu, India.
⁵ Central Research Laboratory, Meenakshi Ammal Dental College, Meenakshi Academy of Higher Education and Research, Maduravoyal, Chennai, Tamil Nadu, India. nalinikrishu@gmail.com.

PMID: 32873908
PMCID: PMC7461147
DOI: 10.1038/s41366-020-00670-9

No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

**Fig. 1**
Furin cleaves the S1/S2 furin-like cleavage site in “S” protein if SARS COV2 virus and mediates viral entry into host cells.

**Fig. 2**
Probable mechanism relating furin to increased mortality of COVID-19 infected diabetes patients.

See this image and copyright information in PMC

Cited by

Healthy Immunity on Preventive Medicine for Combating COVID-19.
Manna PR, Gray ZC, Reddy PH. Manna PR, et al. Nutrients. 2022 Feb 27;14(5):1004. doi: 10.3390/nu14051004. Nutrients. 2022. PMID: 35267980 Free PMC article. Review.
mRNA COVID-19 Vaccines-Facts and Hypotheses on Fragmentation and Encapsulation.
Demongeot J, Fougère C. Demongeot J, et al. Vaccines (Basel). 2022 Dec 24;11(1):40. doi: 10.3390/vaccines11010040. Vaccines (Basel). 2022. PMID: 36679885 Free PMC article.
Molecular docking analysis reveals the functional inhibitory effect of Genistein and Quercetin on TMPRSS2: SARS-COV-2 cell entry facilitator spike protein.
Manjunathan R, Periyaswami V, Mitra K, Rosita AS, Pandya M, Selvaraj J, Ravi L, Devarajan N, Doble M. Manjunathan R, et al. BMC Bioinformatics. 2022 May 16;23(1):180. doi: 10.1186/s12859-022-04724-9. BMC Bioinformatics. 2022. PMID: 35578172 Free PMC article.
COVID-19 and its genomic variants: Molecular pathogenesis and therapeutic interventions.
Manna PR, Gray ZC, Sikdar M, Reddy H. Manna PR, et al. EXCLI J. 2022 Sep 13;21:1196-1221. doi: 10.17179/excli2022-5315. eCollection 2022. EXCLI J. 2022. PMID: 36381644 Free PMC article. Review.
Role of Serine Proteases and Host Cell Receptors Involved in Proteolytic Activation, Entry of SARS-CoV-2 and Its Current Therapeutic Options.
Dessie G, Malik T. Dessie G, et al. Infect Drug Resist. 2021 May 24;14:1883-1892. doi: 10.2147/IDR.S308176. eCollection 2021. Infect Drug Resist. 2021. PMID: 34079299 Free PMC article. Review.

See all "Cited by" articles

References

1. Singh AK, Gupta R, Ghosh A, Misra A. Diabetes in COVID-19: Prevalence, pathophysiology, prognosis and practical considerations. Diabetes Metab Syndr. 2020;14:303–10. doi: 10.1016/j.dsx.2020.04.004. - DOI - PMC - PubMed
1. Bloomgarden ZT. Diabetes and COVID‐19. J Diabetes. 2020;12:347–8. doi: 10.1111/1753-0407.13027. - DOI - PubMed
1. Onder G, Rezza G, Brusaferro S. Case-fatality rate and characteristics of patients dying in relation to COVID-19 in Italy. JAMA. 2020;323:1775–6. - PubMed
1. Yang X, Yu Y, Xu J, Shu H, Xia J, Liu H, et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respiratory Med. 2020;8:475–81. doi: 10.1016/S2213-2600(20)30079-5. - DOI - PMC - PubMed
1. CDC COVID-19 Response Team. Preliminary Estimates of the Prevalence of Selected Underlying Health Conditions Among Patients with Coronavirus Disease 2019 - United States, February 12-March 28, 2020. MMWR Morb Mortal Wkly Rep. 2020;69:382–6. - PMC - PubMed

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions

LinkOut - more resources

Full Text Sources
Medical
- MedlinePlus Health Information

[1] Singh AK, Gupta R, Ghosh A, Misra A. Diabetes in COVID-19: Prevalence, pathophysiology, prognosis and practical considerations. Diabetes Metab Syndr. 2020;14:303–10. doi: 10.1016/j.dsx.2020.04.004. - DOI - PMC - PubMed

[2] Singh AK, Gupta R, Ghosh A, Misra A. Diabetes in COVID-19: Prevalence, pathophysiology, prognosis and practical considerations. Diabetes Metab Syndr. 2020;14:303–10. doi: 10.1016/j.dsx.2020.04.004. - DOI - PMC - PubMed

[3] Bloomgarden ZT. Diabetes and COVID‐19. J Diabetes. 2020;12:347–8. doi: 10.1111/1753-0407.13027. - DOI - PubMed

[4] Bloomgarden ZT. Diabetes and COVID‐19. J Diabetes. 2020;12:347–8. doi: 10.1111/1753-0407.13027. - DOI - PubMed

[5] Onder G, Rezza G, Brusaferro S. Case-fatality rate and characteristics of patients dying in relation to COVID-19 in Italy. JAMA. 2020;323:1775–6. - PubMed

[6] Onder G, Rezza G, Brusaferro S. Case-fatality rate and characteristics of patients dying in relation to COVID-19 in Italy. JAMA. 2020;323:1775–6. - PubMed

[7] Yang X, Yu Y, Xu J, Shu H, Xia J, Liu H, et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respiratory Med. 2020;8:475–81. doi: 10.1016/S2213-2600(20)30079-5. - DOI - PMC - PubMed

[8] Yang X, Yu Y, Xu J, Shu H, Xia J, Liu H, et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respiratory Med. 2020;8:475–81. doi: 10.1016/S2213-2600(20)30079-5. - DOI - PMC - PubMed

[9] CDC COVID-19 Response Team. Preliminary Estimates of the Prevalence of Selected Underlying Health Conditions Among Patients with Coronavirus Disease 2019 - United States, February 12-March 28, 2020. MMWR Morb Mortal Wkly Rep. 2020;69:382–6. - PMC - PubMed

[10] CDC COVID-19 Response Team. Preliminary Estimates of the Prevalence of Selected Underlying Health Conditions Among Patients with Coronavirus Disease 2019 - United States, February 12-March 28, 2020. MMWR Morb Mortal Wkly Rep. 2020;69:382–6. - PMC - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Increased mortality of COVID-19 infected diabetes patients: role of furin proteases

Affiliations

Increased mortality of COVID-19 infected diabetes patients: role of furin proteases

Authors

Affiliations

Conflict of interest statement

Figures

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Medical

Conflict of interest statement

Figures

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

Related information

LinkOut - more resources

Full Text Sources

Medical