Duloxetine-induced hypertensive urgency in type 2 diabetes mellitus with diabetic neuropathy
- PMID: 32874005
- PMCID: PMC7446681
- DOI: 10.4103/ijp.IJP_370_19
Duloxetine-induced hypertensive urgency in type 2 diabetes mellitus with diabetic neuropathy
Abstract
We present a case of hypertensive urgency in a diabetic patient with painful diabetic neuropathy on duloxetine treatment. The patient's blood pressure was high after taking 1-day dose of duloxetine and the patient was diagnosed with hypertensive urgency. The patient was managed with labetalol, leading to reduction in blood pressure. The patient's medication was switched to telmisartan and metoprolol, which leads to resolution of increased blood pressure. This case report is a possible case of hypertensive urgency after the initiation of duloxetine managed with antihypertensives and resolves with the discontinuation of the duloxetine.
Keywords: Duloxetine; hypertensive urgency; painful diabetic neuropathy.
Copyright: © 2020 Indian Journal of Pharmacology.
Conflict of interest statement
There are no conflicts of interest.
References
-
- Yaksh TL. Pharmacology of spinal adrenergic systems which modulate spinal nociceptive processing. Pharmacol Biochem Behav. 1985;22:845–58. - PubMed
-
- Zhuo M, Gebhart GF. Biphasic modulation of spinal nociceptive transmission from the medullary raphe nuclei in the rat. J Neurophysiol. 1997;78:746–58. - PubMed
-
- Mermi O, Atmaca M. Duloxetine-induced hypertension: A case report. Turk Psikiyatri Derg. 2016;27:67–9. - PubMed
-
- Hypertensive Emergencies: Uncontrolled Blood Pressure, Management of Hypertensive Emergencies. [Last accessed on 2019 Jun 11]. Available from: https://emedicine.medscape.com/article/1952052-overview .
-
- Licht CM, de Geus EJ, Seldenrijk A, van Hout HP, Zitman FG, van Dyck R, et al. Depression is associated with decreased blood pressure, but antidepressant use increases the risk for hypertension. Hypertension. 2009;53:631–8. - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
