Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Safety and efficacy of DSP® (Na2EDTA, tannin-rich extract of Castanea sativa, thyme oil and origanum oil) for pigs for fattening

EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) et al. EFSA J. .

Abstract

Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety for the environment and efficacy of DSP ® (a mixture of disodium salt of ethylenediaminetetraacetic acid (Na2 EDTA), tannin-rich extract of Castanea sativa, thyme oil and origanum oil) as a zootechnical feed additive for pigs for fattening. The European Commission request followed an inconclusive opinion of the FEEDAP Panel published in 2016. The applicant submitted additional information to allow the FEEDAP Panel to complete its assessment; these additional data, related to the safety for the environment and the efficacy of the additive, were the subject of this opinion. Concerning safety for the environment, the risk quotient (PEC/PNEC) value for aquatic organisms was < 1, indicating no concerns of DSP ® for the aquatic compartment; no toxicity data for terrestrial organisms were provided and consequently no conclusion on the safety of DSP ® for the terrestrial compartment could be reached, as well as on the risk for groundwater contamination. Based on the results from three studies in pigs for fattening in which final body weight and average daily weight gain were increased, and feed to gain ratio was improved, the FEEDAP Panel concluded that DSP ® has the potential to be efficacious as a zootechnical additive in pigs for fattening.

Keywords: DSP®; Na2EDTA; efficacy; environment; pigs for fattening; safety; zootechnical additives.

PubMed Disclaimer

References

    1. EFSA (European Food Safety Authority), 2008. Technical Guidance of the Scientific Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) for assessing the safety of feed additives for the environment. EFSA Journal 2008;6(10):842, 28 pp. 10.2903/j.efsa.2008.842 - DOI
    1. EFSA FEEDAP Panel (EFSA Panel on Additives and Products or Substances used in Animal Feed), 2012. Guidance for the preparation of dossiers for zootechnical additives. EFSA Journal 2012;10(1):2536, 19 pp. 10.2903/j.efsa.2012.2536 - DOI
    1. EFSA FEEDAP Panel (EFSA Panel on Additives and Products or Substances used in Animal Feed), 2016. Scientific opinion on the safety and efficacy of Diarr‐Stop S Plus® (Na2EDTA, tannin‐rich extract of Castanea sativa, thyme oil and oregano oil) as a feed additive for pigs for fattening. EFSA Journal 2016;14(5):4472, 15 pp. 10.2903/j.efsa.2016.4472 - DOI
    1. EU RAR (European Union Risk Assessment Report), 2004. Tetrasodium ethylenediaminetetraacetate (Na4EDTA). Institute for Health and Consumer Protection. European Chemicals. Bureau Existing Substances. European Commission. Directorate General Joint Research Centre. Available online: https://echa.europa.eu/documents/10162/415c121b-12cd-40a2-bd56-812c57c303ce