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. 2020 Jul 6;12(Suppl 1):8760.
doi: 10.4081/idr.2020.8760. eCollection 2020 Jul 7.

Analysis of lymphocyte T(CD4+) cells expression on severe early childhood caries and free caries

Muhammad Luthfi  1 , Priyawan Rachmadi  2 , Aqsa Sjuhada Oki  1 , Retno Indrawati  1 , Agung Sosiawan  3 , Muhaimin Rifa'i  4
Affiliations

Analysis of lymphocyte T(CD4+) cells expression on severe early childhood caries and free caries

Muhammad Luthfi et al. Infect Dis Rep. .

Abstract

Early childhood caries (ECC) is still one of the many diseases found in children throughout the world. Cariogenic bacteria are a significant risk factor for ECC associated with early colonization and high levels of cariogenic microbes (Streptococcus mutans, S. mutans). Lymphocyte T (CD4+) cells known as helper T cells, are effector cells for mediated host immunity. Naive T cells (CD4+) must be activated to initiate effector function. This activation occurs through interaction with professional antigen- presenting cells (pro-APC), especially dendritic cells that lead to intracellular pathways that regulate T cell receptor (TCR) more specifically against antigen in T cells. Lymphocyte cells from samples were collected from severe early childhood caries (S-ECC) and Free caries aged 5 to 6 years. The subjects were instructed to gargle 10 mL of sterile NaCl 1.5% solution for 30 seconds, and expectorate it into a sterile glass then analyzing T lymphocyte cell (CD4+) expression using flow cytometry. Lymphocyte T (CD4+) cell expression at SECC (6.2525±64482) while in free caries (8.4138±1.10397) with P-value (P=0. 000). Conclusion of lymphocyte T (CD4+) cells expression at S-ECC is lower than that occurring in free caries.

Keywords: Severe early childhood caries; adaptive immunity; lymphocyte T (CD4+) cells expression.

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Figures

Figure 1.
Figure 1.
T lymphocyte (CD4+) cells expression (6.91%) in the saliva of Caries Free.
Figure 2.
Figure 2.
T lymphocytes (CD4+) cells expression (5.60%) in the saliva of S-ECC.
Figure 3.
Figure 3.
T lymphocytes (CD4+) cells Expression (10.24%) in the saliva of Caries Free.
Figure 4.
Figure 4.
T lymphocytes (CD4+) cells Expression (6.64%) in the saliva of S-ECC.
See this image and copyright information in PMC

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