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Review
. 2020 Dec;1482(1):177-192.
doi: 10.1111/nyas.14478. Epub 2020 Sep 1.

Rethinking gastroesophageal reflux disorder

Samuel P Banting  1 , Henry E Badgery  2 , Matthew Read  2   3 , Hiroshi Mashimo  4
Affiliations
Review

Rethinking gastroesophageal reflux disorder

Samuel P Banting et al. Ann N Y Acad Sci. 2020 Dec.

Abstract

Gastroesophageal reflux disease (GERD) is a common clinical condition for which our understanding has evolved over the past decades. It is now considered a cluster of phenotypes with numerous anatomical and physiological abnormalities contributing to its pathophysiology. As such, it is important to first understand the underlying mechanism of the disease process for each patient before embarking on therapeutic interventions. The aim of our paper is to highlight the mechanisms contributing to GERD and review investigations and interpretation of these results. Finally, the paper reviews the available treatment modalities for this condition, ranging from medical intervention, endoscopic options through to surgery and its various techniques.

Keywords: fundoplication; gastroesophageal reflux disease; hiatus hernia; lower esophageal sphincter.

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References

    1. Eusebi, L.H., R. Ratnakumaran, Y. Yuan, et al. 2018. Global prevalence of, and risk factors for, gastro-oesophageal reflux symptoms: a meta-analysis. Gut 67: 430-440.
    1. Katz, P.O., L.B. Gerson & M.F. Vela. 2013. Guidelines for the diagnosis and management of gastroesophageal reflux disease. Am. J. Gastroenterol. 108: 308-328; quiz 29.
    1. Boeckxstaens, G.E. & W.O. Rohof. 2014. Pathophysiology of gastroesophageal reflux disease. Gastroenterol. Clin. North Am. 43: 15-25.
    1. Naini, B.V., R.F. Souza & R.D. Odze. 2016. Barrett's esophagus: a comprehensive and contemporary review for pathologists. Am. J. Surg. Pathol. 40: e45-e66.
    1. Frazzoni, M., M. Piccoli, R. Conigliaro, et al. 2014. Laparoscopic fundoplication for gastroesophageal reflux disease. World J. Gastroenterol. 20: 14272-14279.

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