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. 2020 Oct 27;142(17):1609-1611.
doi: 10.1161/CIRCULATIONAHA.120.050354. Epub 2020 Sep 2.

Severe COVID-19 Is a Microvascular Disease

Charles J Lowenstein  1 , Scott D Solomon  1
Affiliations

Severe COVID-19 Is a Microvascular Disease

Charles J Lowenstein et al. Circulation. .
No abstract available

Keywords: P-selectin; coronavirus; exocytosis; thrombosis; von Willebrand Factor.

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Figures

Figure.
Figure.
Endothelial exocytosis in coronavirus disease 2019 (COVID-19). We propose that the coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) injures endothelial cells. Endothelial cells respond to viral injury by exocytosis, mobilizing granules that release von Willebrand factor and P-selectin. P-selectin plays a dual role, accelerating thrombosis by binding to platelets, and mediating vascular inflammation by interacting with leukocytes.
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