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Editorial
. 2020 Sep 2.
doi: 10.1515/dmdi-2020-0143. Online ahead of print.

Clinical implementation of pharmacogenetics and personalized drug prescription based on e-health: the MedeA initiative

Adrián LLerena  1   2   3 , Eva Peñas-LLedó  1   2 , Fernando de Andrés  1   3 , Carmen Mata-Martín  1   3 , Cristina L Sánchez  1   3 , Agustín Pijierro  1   4 , Jesús Cobaleda  1   2   5
Affiliations
Editorial

Clinical implementation of pharmacogenetics and personalized drug prescription based on e-health: the MedeA initiative

Adrián LLerena et al. Drug Metab Pers Ther. .
No abstract available

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References

    1. Reisberg, S, Krebs, K, Lepamets, M, Kals, M, Mägi, R, Metsalu, K, et al. Translating genotype data of 44,000 biobank participants into clinical pharmacogenetic recommendations: challenges and solutions. Genet Med 2019 Jun;21:1345–54. https://doi.org/10.1038/s41436-018-0337-5.
    1. LLerena, A, Peñas-Lledó, EM. Metabolic phenotype prediction from genotyping data: a bottleneck for the implementation of pharmacogenetics in drug development and clinical practice. Drug Metab Pers Ther 2015;30:143–5. https://doi.org/10.1515/dmdi-2020-0143.
    1. LLerena, A, Berecz, R, de la Rubia, A, Fernández-Salguero, P, Dorado, P. Effect of thioridazine dosage on the debrisoquine hydroxylation phenotype in psychiatric patients with different CYP2D6 genotypes. Ther Drug Monit 2001 Dec;23:616–20. https://doi.org/10.1097/00007691-200112000-00004.
    1. Llerena, A, Berecz, R, de la Rubia, A, Norberto, MJ, Benítez, J. Use of the mesoridazine/thioridazine ratio as a marker for CYP2D6 enzyme activity. Ther Drug Monit 2000;22:397–401. https://doi.org/10.1097/00007691-200008000-00006.
    1. Berecz, R, LLerena, A, de la Rubia, A, Gómez, J, Kellermann, M, Dorado, P, et al. Relationship between risperidone and 9-hydroxy-risperidone plasma concentrations and CYP2D6 enzyme activity in psychiatric patients. Pharmacopsychiatry 2002 Nov;35:231–4. https://doi.org/10.1055/s-2002-36389.

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