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Comment
. 2020 Sep 1;32(3):328-330.
doi: 10.1016/j.cmet.2020.08.005.

Not Chopped Liver-A Careful, Fate-Mapping Study of Macrophages in NASH

Maria E Moreno-Fernandez  1 , Emily R Miraldi  2 , Senad Divanovic  3
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Not Chopped Liver-A Careful, Fate-Mapping Study of Macrophages in NASH

Maria E Moreno-Fernandez et al. Cell Metab. .
Free article

Abstract

Macrophages are central to the pathogenesis of non-alcoholic steatohepatitis (NASH). However, the identities and functional relationships between tissue-resident and tissue-recruited macrophages in NASH remain poorly understood. A recent study from Seidman et al. (2020) elucidates, at single-cell resolution, the fates, niches, and regulatory landscapes of liver tissue-resident and tissue-recruited macrophage populations in NASH.

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Conflict of interest statement

Declaration of Interests S.D. is a consultant for Janssen Research & Development.

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