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Comment
. 2020 Sep 1;32(3):331-333.
doi: 10.1016/j.cmet.2020.08.003.

An Antibody Attack against Body Wasting in Cancer

Maria Rohm  1 , Stephan Herzig  2
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Comment

An Antibody Attack against Body Wasting in Cancer

Maria Rohm et al. Cell Metab. .
Free article

Abstract

Cachexia is a devastating, non-curable condition in many cancer patients that is marked by severe wasting of the muscle and fat tissue. Its prevention has been hampered by an insufficient knowledge of the underlying molecular mechanism(s) that lead to its pathogenesis. Suriben et al. (2020) now report the development and characterization of an antagonistic antibody for the previously identified GDF15-GFRAL axis that efficiently blocks tumor-induced body wasting in experimental animals.

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  • Antibody-mediated inhibition of GDF15-GFRAL activity reverses cancer cachexia in mice.
    Suriben R, Chen M, Higbee J, Oeffinger J, Ventura R, Li B, Mondal K, Gao Z, Ayupova D, Taskar P, Li D, Starck SR, Chen HH, McEntee M, Katewa SD, Phung V, Wang M, Kekatpure A, Lakshminarasimhan D, White A, Olland A, Haldankar R, Solloway MJ, Hsu JY, Wang Y, Tang J, Lindhout DA, Allan BB. Suriben R, et al. Nat Med. 2020 Aug;26(8):1264-1270. doi: 10.1038/s41591-020-0945-x. Epub 2020 Jul 13. Nat Med. 2020. PMID: 32661391

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