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Review
. 2020 Aug 31;10(9):356.
doi: 10.3390/metabo10090356.

Lipidomics Issues on Human Positive ssRNA Virus Infection: An Update

David Balgoma  1 , Luis Gil-de-Gómez  2 , Olimpio Montero  3
Affiliations
Review

Lipidomics Issues on Human Positive ssRNA Virus Infection: An Update

David Balgoma et al. Metabolites. .

Abstract

The pathogenic mechanisms underlying the Biology and Biochemistry of viral infections are known to depend on the lipid metabolism of infected cells. From a lipidomics viewpoint, there are a variety of mechanisms involving virus infection that encompass virus entry, the disturbance of host cell lipid metabolism, and the role played by diverse lipids in regard to the infection effectiveness. All these aspects have currently been tackled separately as independent issues and focused on the function of proteins. Here, we review the role of cholesterol and other lipids in ssRNA+ infection.

Keywords: SARS-CoV; cholesterol; lipid metabolism; lipidomics; membrane fusion; phosphatidylinositol; sphingolipids; ssRNA+ virus.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Relationship between the virus entry and replication with the lipidome. SREBP, sterol regulatory element binding protein; SFA, saturated fatty acid. SARS-CoV-2 artwork was modified from a work from We Are Covert, who allows anyone to use it for any purpose including unrestricted redistribution, commercial use, and modification.
Figure 2
Figure 2
Structure of the most relevant lipids in virus infection is illustrated. Hydroxyl (HO) and oxygen (O) atoms potentially involved in the interaction with the fusion peptide or fusion loop are marked in red in cholesterol and sphingomyelin. The basic ceramide structure is marked in blue in the sphigomyelin structure. In phosphatidylinositol (PI), the hydroxyl groups that can be esterified with phosphate at the positions 3, 4, and 5 of the myo-inositol group to render PIP (PI3P or PI4P), PIP2 (PI(3,4)P or PI(4,5)P), and PIP3 (PI(3,4,5)P), which are marked in red, blue, and violet, respectively, are shown.
Figure 3
Figure 3
Comprehensive view of the virus replication process and the main lipids involved in every step.
See this image and copyright information in PMC

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