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. 2020 Aug 17:2020:8822997.
doi: 10.1155/2020/8822997. eCollection 2020.

Survival Analysis of Clinical Cases of Caseous Lymphadenitis of Goats in North Shoa, Ethiopia

Erdachew Yitagesu  1 , Enyiew Alemnew  1 , Abebe Olani  2 , Tadiwos Asfaw  1 , Chekol Demis  1
Affiliations

Survival Analysis of Clinical Cases of Caseous Lymphadenitis of Goats in North Shoa, Ethiopia

Erdachew Yitagesu et al. Vet Med Int. .

Abstract

Caseous lymphadenitis (CLA) is a bacterial disease of small ruminants causing abscesses in lymph nodes of the body and internal organs. A longitudinal study from 2011 to 2019 was undertaken at Ataye site of Debre Birhan Research Center to estimate the prevalence and incidence, identify associated risk factors, and characterize the causative bacteria. 1025 goats were followed up for the CLA study. Survival analysis was done using SAS 9.4 software program. Biochemical tests and Biolog microbial identification system were used to characterize the bacteria. In the recurrent survival data analysis, there were 1,138 clinical observations and 214 CLA cases (18.8% prevalence) based on clinical diagnosis. The incidence rate was 0.14 cases per animal year. From a total of 214 cases, 130 have occurred once and 84 cases are recurrent cases following first cases. The cumulative failure rates were 68% for newborn and 64% for yearling age groups. The parotid lymph node was the most frequently affected site. Proportional hazard analysis results showed that sex, age, and breed were associated (p < 0.05) with CLA incidence. Females, newborn age group, Boer, and Boer × Central Highland Goat (CHG) were at higher risks compared to males, yearling age group, and CHG goats, respectively. The present study indicated that a high incidence rate of CLA in the goat farm is difficult to control and prevent because of its poor response to clinical treatment. Thus, control and prevention should focus on the spread of the disease such as isolation of clinically sick animals, culling, and vaccination of flocks.

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Conflict of interest statement

The authors declare that there are no conflicts of interest regarding the publication of this paper.

Figures

Figure 1
Figure 1
Map of Ethiopia showing the region, zone, district, and town where the study site is located.
Figure 2
Figure 2
Images of CLA prescapular LN case (a), incised retropharyngeal LN case (b), sample culture on blood agar (c), and Gram stain of the bacteria (d).
Figure 3
Figure 3
Kaplan–Meier survival function curve of caseous lymphadenitis cases from birth or entry to farm to 60 months of the follow-up period.
See this image and copyright information in PMC

References

    1. Ivanović S., Žutić M., Pavlović I., Žujović M. Caseous lymphadenitis in goats. Biotechnology in Animal Husbandry. 2009;25(5-6-2):999–1007.
    1. Williamson L. H. Caseous lymphadenitis in small ruminants. Veterinary Clinics of North America: Food Animal Practice. 2001;17(2):359–371. doi: 10.1016/s0749-0720(15)30033-5. - DOI - PubMed
    1. Baird G. J., Fontaine M. C. Corynebacterium pseudotuberculosis and its role in ovine caseous lymphadenitis. Journal of Comparative Pathology. 2007;137(4):179–210. doi: 10.1016/j.jcpa.2007.07.002. - DOI - PubMed
    1. Quin P., Carter M., Markey B., Carter E. Clinical Veterinary Microbiology. London, UK: Elsevier; 2004. Corynebacterium species and Rhodococcus equi; pp. 137–143.
    1. Baird G. J., Malone F. E. Control of caseous lymphadenitis in six sheep flocks using clinical examination and regular ELISA testing. Veterinary Record. 2010;166(12):358–362. doi: 10.1136/vr.b4806. - DOI - PubMed

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