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Observational Study
. 2020 Aug 17:2020:1860268.
doi: 10.1155/2020/1860268. eCollection 2020.

Relation of Fibrinogen-to-Albumin Ratio to Severity of Coronary Artery Disease and Long-Term Prognosis in Patients with Non-ST Elevation Acute Coronary Syndrome

Mingkang Li  1 , Chengchun Tang  2 , Erfei Luo  1 , Yuhan Qin  1 , Dong Wang  2 , Gaoliang Yan  2
Affiliations
Observational Study

Relation of Fibrinogen-to-Albumin Ratio to Severity of Coronary Artery Disease and Long-Term Prognosis in Patients with Non-ST Elevation Acute Coronary Syndrome

Mingkang Li et al. Biomed Res Int. .

Abstract

Previous studies showed that fibrinogen-to-albumin ratio (FAR) regarded as a novel inflammatory and thrombotic biomarker was the risk factor for coronary artery disease (CAD). In this study, we sought to evaluate the relationship between FAR and severity of CAD, long-term prognosis in non-ST elevation acute coronary syndrome (NSTE-ACS) patients firstly implanted with drug-eluting stent (DES). A total of 1138 consecutive NSTE-ACS patients firstly implanted with DES from January 2017 to December 2018 were recruited in this study. Patients were divided into tertiles according to FAR levels (Group 1: ≤8.715%; Group 2: 8.715%~10.481%; and Group 3: >10.481%). The severity of CAD was evaluated using the Gensini Score (GS). The endpoints were major adverse cardiovascular events (MACE), including all-cause mortality, myocardial reinfarction, and target vessel revascularization (TVR). Positive correlation was detected by Spearman's rank correlation coefficient analysis between FAR and GS (r = 0.170, P < 0.001). On multivariate logistic analysis, FAR was an independent predictor of severe CAD (OR: 1.060; 95% CI: 1.005~1.118; P < 0.05). Multivariate Cox regression analysis indicated that FAR was an independent prognostic factor for MACE at 30 days, 6 months, and 1 year after DES implantation (HR: 1.095; 95% CI: 1.011~1.186; P = 0.025. HR: 1.076; 95% CI: 1.009~1.147; P = 0.026. HR: 1.080; 95% CI: 1.022~1.141; P = 0.006). Furthermore, adding FAR to the model of established risk factors, the C-statistic increased from 0.706 to 0.720, 0.650 to 0.668, and 0.611 to 0.632, respectively. And the models had incremental prognostic value for MACE, especially for 1-year MACE (NRI: 13.6% improvement, P = 0.044; IDI: 0.6% improvement, P = 0.042). In conclusion, FAR was associated independently with the severity of CAD and prognosis, helping to improve risk stratification in NSTE-ACS patients firstly implanted with DES.

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Conflict of interest statement

The authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest or nonfinancial interest in the subject matter or materials discussed in this manuscript.

Figures

Figure 1
Figure 1
Flow diagram of participant selection.
Figure 2
Figure 2
Statistical histogram and boxplot display the distribution of FAR among the study cohort.
Figure 3
Figure 3
Correlations of FAR with TnI and CK-MB.
Figure 4
Figure 4
Scatter dot displays the relationship between FAR and GS.
Figure 5
Figure 5
The Kaplan-Meier analysis curve of MACE and TVR among 3 groups.
See this image and copyright information in PMC

References

    1. Amsterdam E. A., Wenger N. K., Brindis R. G., et al. 2014 AHA/ACC guideline for the management of patients with non-ST-elevation acute coronary Syndromes. Circulation. 2014;130(25):e344–e426. doi: 10.1161/CIR.0000000000000134. - DOI - PubMed
    1. Ibanez B., James S., Agewall S., et al. 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: the Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC) European Heart Journal. 2018;39(2):119–177. doi: 10.1093/eurheartj/ehx393. - DOI - PubMed
    1. Virani S. S., Alonso A., Benjamin E. J., et al. Heart Disease and Stroke Statistics-2020 update: a report from the American Heart Association. Circulation. 2020;141(9):e139–e596. doi: 10.1161/CIR.0000000000000757. - DOI - PubMed
    1. Bentzon J. F., Otsuka F., Virmani R., Falk E. Mechanisms of plaque formation and rupture. Circulation Research. 2014;114(12):1852–1866. doi: 10.1161/CIRCRESAHA.114.302721. - DOI - PubMed
    1. Falk E., Shah P. K., Fuster V. Coronary plaque disruption. Circulation. 1995;92(3):657–671. doi: 10.1161/01.CIR.92.3.657. - DOI - PubMed

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