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. 2021 Feb;268(2):582-589.
doi: 10.1007/s00415-020-10204-y. Epub 2020 Sep 2.

Parkinson's disease laterality: a 11C-PE2I PET imaging study

Andreas-Antonios Roussakis #  1 , Zhou Zeng #  1   2 , Nicholas P Lao-Kaim  1 , Antonio Martin-Bastida  1   3 , Paola Piccini  4 ; TRANSEURO consortium
Collaborators, Affiliations

Parkinson's disease laterality: a 11C-PE2I PET imaging study

Andreas-Antonios Roussakis et al. J Neurol. 2021 Feb.

Abstract

Asymmetry of striatal dopaminergic deficits and motor symptoms is a typical characteristic of idiopathic Parkinson's disease (PD). This study aims to characterise the trend of asymmetry in moderate-stage PD. We performed a 19-month longitudinal study in 27 patients with PET-CT imaging and appropriate clinical assessments. 11C-PE2I non-displaceable binding potential (BPND) was calculated bilaterally for the striatum at baseline and follow-up to estimate the in vivo density of striatal dopamine transporters (DAT). Changes in striatal 11C-PE2I BPND over time were more prominent in the ipsilateral as compared to contralateral side. Changes in MDS-UPDRS-III (motor component of the Movement Disorders Society Unified PD Rating Scale) were not different between the clinically most and least affected body sides. Our data support that the asymmetry in striatal dopaminergic degeneration becomes less prominent in moderate-stage PD. In contrast, during the above period, the asymmetry of motor symptoms was maintained between the clinically most and least affected body sides.

Keywords: Asymmetry; Dopamine transporter; Parkinson’s disease; Positron emission tomography; Striatum.

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Conflict of interest statement

The authors have no conflicting financial interests.

Figures

Fig. 1
Fig. 1
Changes in striatal 11C-PE2I BPND values and motor severity (MDS-UPDRS-III scores) over 19 months. A significant time × side interaction was observed for striatal 11C-PE2I BPND values (p < 0.05; repeated measure analysis of covariance; a, b) but not for MDS-UPDRS-III scores (c). Dots represent the individual patients; lines connect baseline and follow-up mean values. BPND non-displaceable binding potential, MDS-UPDRS Movement Disorders Society Unified Parkinson's Disease Rating Scale, MDS-UPDRS-III motor component of MDS-UPDRS, least affected the least clinical affected body side, most affected the most clinical affected body side
See this image and copyright information in PMC

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