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. 2020 Oct 2;85(19):12777-12784.
doi: 10.1021/acs.joc.0c01672. Epub 2020 Sep 17.

Copper(II)-Catalyzed Direct Amination of 1-Naphthylamines at the C8 Site

Conghui Zu  1 , Tingfang Zhang  1 , Fan Yang  1 , Yusheng Wu  2 , Yangjie Wu  1
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Copper(II)-Catalyzed Direct Amination of 1-Naphthylamines at the C8 Site

Conghui Zu et al. J Org Chem. .

Abstract

A new and simple protocol for C8-H amination of 1-naphthylamine derivatives was developed using copper salt and di-tert-butyl peroxide (DTBP) as the catalyst and oxidant, respectively. This reaction proceeded smoothly under the additive and solvent-free conditions. In addition, this amination showed excellent regioselectivity and could tolerate various functional groups.

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