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. 2020 Sep 3;324(15):1565-1567.
doi: 10.1001/jama.2020.17052. Online ahead of print.

Cytokine Levels in Critically Ill Patients With COVID-19 and Other Conditions

Matthijs Kox  1 , Nicole J B Waalders  1 , Emma J Kooistra  1 , Jelle Gerretsen  1 , Peter Pickkers  1
Affiliations

Cytokine Levels in Critically Ill Patients With COVID-19 and Other Conditions

Matthijs Kox et al. JAMA. .

Abstract

This study compares levels of tumor necrosis factor α, IL-6, and IL-8 in critically ill patients with coronavirus disease 2019 (COVID-19) vs those with other critical illness to better characterize the contribution of cytokine storm to COVID-19 pathophysiology.

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Conflict of interest statement

Conflict of Interest Disclosures: None reported.

Figures

Figure.
Figure.. Cytokine Levels in Critically Ill Patients With Coronavirus Disease 2019 (COVID-19) and Other Conditions
Plasma concentrations of tumor necrosis factor (TNF) (A), IL-6 (B), and IL-8 (C) in patients with COVID-19 and acute respiratory distress syndrome (ARDS) (n = 46), septic shock with ARDS (n = 51), septic shock without ARDS (n = 15), out-of-hospital cardiac arrest (OHCA; n = 30), and multiple traumas (n = 62). Data are presented as scatter plots with red horizontal bars indicating the geometric mean levels. aP < .01 vs COVID-19 with ARDS. bP < .001 vs COVID-19 with ARDS. cP < .05 vs COVID-19 with ARDS.
See this image and copyright information in PMC

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