Single-cell transcriptional profile of ACE2 in healthy and failing human hearts

doi:10.1007/s11427-020-1787-5

. 2021 Apr;64(4):652-655.

doi: 10.1007/s11427-020-1787-5. Epub 2020 Sep 1.

Single-cell transcriptional profile of ACE2 in healthy and failing human hearts

Yitian Zhou^#^{1

2}, Yongfa Huang^#², Xiaomin Song^#¹, Xiaoxiao Guo^#², Junling Pang¹, Jing Wang³, Shuyang Zhang⁴, Chen Wang⁵

Affiliations

¹ State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Department of Pathophysiology, Peking Union Medical College, Beijing, 100730, China.
² Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, China.
³ State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Department of Pathophysiology, Peking Union Medical College, Beijing, 100730, China. wangjing@ibms.pumc.edu.cn.
⁴ Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, China. shuyangzhang103@163.com.
⁵ State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Department of Physiology, Peking Union Medical College, Beijing, 100730, China.

^# Contributed equally.

PMID: 32880862
PMCID: PMC7471532
DOI: 10.1007/s11427-020-1787-5

Single-cell transcriptional profile of ACE2 in healthy and failing human hearts

Yitian Zhou et al. Sci China Life Sci. 2021 Apr.

. 2021 Apr;64(4):652-655.

doi: 10.1007/s11427-020-1787-5. Epub 2020 Sep 1.

Authors

Yitian Zhou^#^{1

2}, Yongfa Huang^#², Xiaomin Song^#¹, Xiaoxiao Guo^#², Junling Pang¹, Jing Wang³, Shuyang Zhang⁴, Chen Wang⁵

Affiliations

¹ State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Department of Pathophysiology, Peking Union Medical College, Beijing, 100730, China.
² Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, China.
³ State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Department of Pathophysiology, Peking Union Medical College, Beijing, 100730, China. wangjing@ibms.pumc.edu.cn.
⁴ Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, China. shuyangzhang103@163.com.
⁵ State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Department of Physiology, Peking Union Medical College, Beijing, 100730, China.

^# Contributed equally.

PMID: 32880862
PMCID: PMC7471532
DOI: 10.1007/s11427-020-1787-5

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References

1. Chen L, Li X, Chen M, Feng Y, Xiong C. The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2. Cardiovasc Res. 2020;116:1097–1100. doi: 10.1093/cvr/cvaa078. - DOI - PMC - PubMed
1. Chiaverina G, di Blasio L, Monica V, Accardo M, Palmiero M, Peracino B, Vara-Messler M, Puliafito A, Primo L. Dynamic interplay between pericytes and endothelial cells during sprouting angiogenesis. Cells. 2019;8:1109. doi: 10.3390/cells8091109. - DOI - PMC - PubMed
1. Escher R, Breakey N, Lämmle B. Severe COVID-19 infection associated with endothelial activation. Thromb Res. 2020;190:62. doi: 10.1016/j.thromres.2020.04.014. - DOI - PMC - PubMed
1. Han X, Wang R, Zhou Y, Fei L, Sun H, Lai S, Saadatpour A, Zhou Z, Chen H, Ye F, et al. Mapping the mouse cell atlas by microwell-seq. Cell. 2018;172:1091–1107.e17. doi: 10.1016/j.cell.2018.02.001. - DOI - PubMed
1. Humeres C, Frangogiannis NG. Fibroblasts in the infarcted, remodeling, and failing heart. JACC Basic Transl Sci. 2019;4:449–467. doi: 10.1016/j.jacbts.2019.02.006. - DOI - PMC - PubMed

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[1] Chen L, Li X, Chen M, Feng Y, Xiong C. The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2. Cardiovasc Res. 2020;116:1097–1100. doi: 10.1093/cvr/cvaa078. - DOI - PMC - PubMed

[2] Chen L, Li X, Chen M, Feng Y, Xiong C. The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2. Cardiovasc Res. 2020;116:1097–1100. doi: 10.1093/cvr/cvaa078. - DOI - PMC - PubMed

[3] Chiaverina G, di Blasio L, Monica V, Accardo M, Palmiero M, Peracino B, Vara-Messler M, Puliafito A, Primo L. Dynamic interplay between pericytes and endothelial cells during sprouting angiogenesis. Cells. 2019;8:1109. doi: 10.3390/cells8091109. - DOI - PMC - PubMed

[4] Chiaverina G, di Blasio L, Monica V, Accardo M, Palmiero M, Peracino B, Vara-Messler M, Puliafito A, Primo L. Dynamic interplay between pericytes and endothelial cells during sprouting angiogenesis. Cells. 2019;8:1109. doi: 10.3390/cells8091109. - DOI - PMC - PubMed

[5] Escher R, Breakey N, Lämmle B. Severe COVID-19 infection associated with endothelial activation. Thromb Res. 2020;190:62. doi: 10.1016/j.thromres.2020.04.014. - DOI - PMC - PubMed

[6] Escher R, Breakey N, Lämmle B. Severe COVID-19 infection associated with endothelial activation. Thromb Res. 2020;190:62. doi: 10.1016/j.thromres.2020.04.014. - DOI - PMC - PubMed

[7] Han X, Wang R, Zhou Y, Fei L, Sun H, Lai S, Saadatpour A, Zhou Z, Chen H, Ye F, et al. Mapping the mouse cell atlas by microwell-seq. Cell. 2018;172:1091–1107.e17. doi: 10.1016/j.cell.2018.02.001. - DOI - PubMed

[8] Han X, Wang R, Zhou Y, Fei L, Sun H, Lai S, Saadatpour A, Zhou Z, Chen H, Ye F, et al. Mapping the mouse cell atlas by microwell-seq. Cell. 2018;172:1091–1107.e17. doi: 10.1016/j.cell.2018.02.001. - DOI - PubMed

[9] Humeres C, Frangogiannis NG. Fibroblasts in the infarcted, remodeling, and failing heart. JACC Basic Transl Sci. 2019;4:449–467. doi: 10.1016/j.jacbts.2019.02.006. - DOI - PMC - PubMed

[10] Humeres C, Frangogiannis NG. Fibroblasts in the infarcted, remodeling, and failing heart. JACC Basic Transl Sci. 2019;4:449–467. doi: 10.1016/j.jacbts.2019.02.006. - DOI - PMC - PubMed

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Single-cell transcriptional profile of ACE2 in healthy and failing human hearts

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Single-cell transcriptional profile of ACE2 in healthy and failing human hearts

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