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Review
. 2020 Dec 1;16(12):3001-3010.
doi: 10.1080/21645515.2020.1794684. Epub 2020 Sep 3.

Current perspective on diagnosis, epidemiological assessment, prevention strategies, and potential therapeutic interventions for severe acute respiratory infections caused by 2019 novel coronavirus (SARS-CoV-2)

Komal Rizwan  1 , Tahir Rasheed  2 , Shakeel Ahmad Khan  3 , Muhammad Bilal  4 , Tahir Mahmood  5
Affiliations
Review

Current perspective on diagnosis, epidemiological assessment, prevention strategies, and potential therapeutic interventions for severe acute respiratory infections caused by 2019 novel coronavirus (SARS-CoV-2)

Komal Rizwan et al. Hum Vaccin Immunother. .

Abstract

Coronaviruses are single-stranded RNA viruses that cause severe respiratory, enteric, and systemic infections in a vast range of hosts, including man, fish, mammals, and avian. Scientific interest has heightened on coronaviruses after the emergence of the 2019 novel Coronavirus (SARS-CoV-2). This review provides current perspectives on morphology, genetic diversity, transmission characteristics, replication cycle, diagnostic approaches, epidemiological assessment, and prevention strategies against the SARS-CoV-2. Moreover, different potential biotherapeutics such as small drug molecules, different vaccines, and immunotherapies to control severe acute respiratory infections caused by 2019 novel coronavirus (SARS-CoV-2) are repurposed and discussed with different mechanistic approaches. The current growth trends of the SARS-CoV-2/COVID-19 outbreak globally and preventive measures are briefly discussed. Furthermore, the lessons learned from the COVID-19 outbreak, so far, concluding remarks and future directions for controlling for COVID-19, are also recommended for a safer tomorrow.

Keywords: COVID-19; Coronavirus; diagnosis; epidemiology; prevention strategies; therapeutic candidates; transmission characteristics.

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Figures

Figure 1.
Figure 1.
Structure presentation of Coronavirus particle.
Figure 2.
Figure 2.
The symptoms of SARS-CoV-2 infections with respect to the rate
Figure 3.
Figure 3.
Replication process steps of coronavirus with respect to potential target-sites for repurposing therapeutic drug molecules and vaccines
Figure 4.
Figure 4.
Potential drug candidates’ patents with respect to the targeting proteins of coronavirus
Figure 5.
Figure 5.
Drug candidates that can be potentially evaluated for their effectiveness against SARS-CoV-2 infections
Figure 6.
Figure 6.
Different vaccine candidates in clinical phase for the treatment of COVID-19. The Figure was created with “BioRender.com” template and exported under the terms of premium subscription
Figure 7.
Figure 7.
Potential repurposed monoclonal antibodies for the treatment of COVID-19. The Figure was created with “BioRender.com” template and exported under the terms of premium subscription
Figure 8.
Figure 8.
Principles of herd immunity and social distancing. The Figure was created with “BioRender.com” template and exported under the terms of premium subscription
See this image and copyright information in PMC

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