Circulating Plasminogen Concentration at Admission in Patients with Coronavirus Disease 2019 (COVID-19)

doi:10.1055/s-0040-1715454

. 2020 Oct;46(7):859-862.

doi: 10.1055/s-0040-1715454. Epub 2020 Sep 3.

Circulating Plasminogen Concentration at Admission in Patients with Coronavirus Disease 2019 (COVID-19)

Brandon Michael Henry¹, Stefanie W Benoit^{2

3}, Jonathan Hoehn⁴, Giuseppe Lippi⁵, Emmanuel J Favaloro⁶, Justin L Benoit⁴

Affiliations

¹ Cardiac Intensive Care Unit, The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
² Division of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
³ Department of Pediatrics, University of Cincinnati, College of Medicine, Ohio.
⁴ Department of Emergency Medicine, University of Cincinnati, Cincinnati, Ohio.
⁵ Section of Clinical Biochemistry, Department of Neuroscience, Biomedicine and Movement, University of Verona, Verona, Italy.
⁶ Department of Haematology, Sydney Centres for Thrombosis and Haemostasis, NSW Health Pathology, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, New South Wales, Australia.

PMID: 32882718
PMCID: PMC7645831
DOI: 10.1055/s-0040-1715454

Circulating Plasminogen Concentration at Admission in Patients with Coronavirus Disease 2019 (COVID-19)

Brandon Michael Henry et al. Semin Thromb Hemost. 2020 Oct.

. 2020 Oct;46(7):859-862.

doi: 10.1055/s-0040-1715454. Epub 2020 Sep 3.

Authors

Brandon Michael Henry¹, Stefanie W Benoit^{2

3}, Jonathan Hoehn⁴, Giuseppe Lippi⁵, Emmanuel J Favaloro⁶, Justin L Benoit⁴

Affiliations

¹ Cardiac Intensive Care Unit, The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
² Division of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
³ Department of Pediatrics, University of Cincinnati, College of Medicine, Ohio.
⁴ Department of Emergency Medicine, University of Cincinnati, Cincinnati, Ohio.
⁵ Section of Clinical Biochemistry, Department of Neuroscience, Biomedicine and Movement, University of Verona, Verona, Italy.
⁶ Department of Haematology, Sydney Centres for Thrombosis and Haemostasis, NSW Health Pathology, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, New South Wales, Australia.

PMID: 32882718
PMCID: PMC7645831
DOI: 10.1055/s-0040-1715454

No abstract available

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Conflict of interest statement

None.

Figures

**Fig. 1**
Plasminogen concentration in COVID-19-positive patients versus COVID-19-negative sick controls ( A ), COVID-19-positive patients hospitalized versus discharged at initial presentation in emergency department ( B ), and in COVID-19-positive patients requiring ICU admission versus no ICU admission ( C ). COVID-19, coronavirus disease 2019; ns, nonsignificant.

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References

1. Lippi G, Sanchis-Gomar F, Henry B M. Coronavirus disease 2019 (COVID-19): the portrait of a perfect storm. Ann Transl Med. 2020;8(07):497. - PMC - PubMed
1. Lippi G, Sanchis-Gomar F, Henry B M. COVID-19: unravelling the clinical progression of nature's virtually perfect biological weapon. Ann Transl Med. 2020;8(11):693. - PMC - PubMed
1. Henry B M, de Oliveira M HS, Benoit S, Plebani M, Lippi G. Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): a meta-analysis. Clin Chem Lab Med. 2020;58(07):1021–1028. - PubMed
1. Wright F L, Vogler T O, Moore E E.Fibrinolysis shutdown correlation with thromboembolic events in severe COVID-19 infectionJ Am Coll Surg2020; Doi: 10.1016/j.jamcollsurg.2020.05.007 (epub ahead of print)
1. Henry B M, Vikse J, Benoit S, Favaloro E J, Lippi G. Hyperinflammation and derangement of renin-angiotensin-aldosterone system in COVID-19: a novel hypothesis for clinically suspected hypercoagulopathy and microvascular immunothrombosis. Clin Chim Acta. 2020;507:167–173. - PMC - PubMed

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[1] Lippi G, Sanchis-Gomar F, Henry B M. Coronavirus disease 2019 (COVID-19): the portrait of a perfect storm. Ann Transl Med. 2020;8(07):497. - PMC - PubMed

[2] Lippi G, Sanchis-Gomar F, Henry B M. Coronavirus disease 2019 (COVID-19): the portrait of a perfect storm. Ann Transl Med. 2020;8(07):497. - PMC - PubMed

[3] Lippi G, Sanchis-Gomar F, Henry B M. COVID-19: unravelling the clinical progression of nature's virtually perfect biological weapon. Ann Transl Med. 2020;8(11):693. - PMC - PubMed

[4] Lippi G, Sanchis-Gomar F, Henry B M. COVID-19: unravelling the clinical progression of nature's virtually perfect biological weapon. Ann Transl Med. 2020;8(11):693. - PMC - PubMed

[5] Henry B M, de Oliveira M HS, Benoit S, Plebani M, Lippi G. Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): a meta-analysis. Clin Chem Lab Med. 2020;58(07):1021–1028. - PubMed

[6] Henry B M, de Oliveira M HS, Benoit S, Plebani M, Lippi G. Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): a meta-analysis. Clin Chem Lab Med. 2020;58(07):1021–1028. - PubMed

[7] Wright F L, Vogler T O, Moore E E.Fibrinolysis shutdown correlation with thromboembolic events in severe COVID-19 infectionJ Am Coll Surg2020; Doi: 10.1016/j.jamcollsurg.2020.05.007 (epub ahead of print)

[8] Wright F L, Vogler T O, Moore E E.Fibrinolysis shutdown correlation with thromboembolic events in severe COVID-19 infectionJ Am Coll Surg2020; Doi: 10.1016/j.jamcollsurg.2020.05.007 (epub ahead of print)

[9] Henry B M, Vikse J, Benoit S, Favaloro E J, Lippi G. Hyperinflammation and derangement of renin-angiotensin-aldosterone system in COVID-19: a novel hypothesis for clinically suspected hypercoagulopathy and microvascular immunothrombosis. Clin Chim Acta. 2020;507:167–173. - PMC - PubMed

[10] Henry B M, Vikse J, Benoit S, Favaloro E J, Lippi G. Hyperinflammation and derangement of renin-angiotensin-aldosterone system in COVID-19: a novel hypothesis for clinically suspected hypercoagulopathy and microvascular immunothrombosis. Clin Chim Acta. 2020;507:167–173. - PMC - PubMed

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Circulating Plasminogen Concentration at Admission in Patients with Coronavirus Disease 2019 (COVID-19)

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Circulating Plasminogen Concentration at Admission in Patients with Coronavirus Disease 2019 (COVID-19)

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