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Editorial
. 2020 Oct;39(10):1050-1069.
doi: 10.1016/j.healun.2020.06.024. Epub 2020 Jul 10.

Report from the 2018 consensus conference on immunomodulating agents in thoracic transplantation: Access, formulations, generics, therapeutic drug monitoring, and special populations

Adam B Cochrane  1 , Haifa Lyster  2 , JoAnn Lindenfeld  3 , Christina Doligalski  4 , David Baran  5 , Colleen Yost  6 , Michael Shullo  7 , Martin Schweiger  8 , David Weill  9 , Linda Stuckey  10 , Steven Ivulich  11 , Janet Scheel  12 , Lisa Peters  13 , Monica Colvin  14 , Kyle Dawson  15 , Reda Girgis  16 , Phillip Weeks  17 , Tracy Tse  18 , Stuart Russell  19 , Maureen Flattery  20 , Doug Jennings  21 , Michelle Kittleson  22 , Tara Miller  19 , Tam Khuu  23 , Tamara Claridge  24 , Patricia Uber  25 , Katrina Ford  26 , Christopher R Ensor  27 , Kathleen Simpson  28 , Anne Dipchand  29 , Robert L Page 2nd  30
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Editorial

Report from the 2018 consensus conference on immunomodulating agents in thoracic transplantation: Access, formulations, generics, therapeutic drug monitoring, and special populations

Adam B Cochrane et al. J Heart Lung Transplant. 2020 Oct.

Abstract

In 2009, the International Society for Heart and Lung Transplantation recognized the importance and challenges surrounding generic drug immunosuppression. As experience with generics has expanded and comfort has increased, substantial issues have arisen since that time with other aspects of immunomodulation that have not been addressed, such as access to medicines, alternative immunosuppression formulations, additional generics, implications on therapeutic drug monitoring, and implications for special populations such as pediatrics and older adults. The aim of this consensus document is to address critically each of these concerns, expand on the challenges and barriers, and provide therapeutic considerations for practitioners who manage patients who need to undergo or have undergone cardiothoracic transplantation.

Keywords: generic immunosuppression; heart transplantation; immunosuppression; lung transplantation; pediatric transplantation.

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