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Comment
. 2020 Sep 3;5(1):184.
doi: 10.1038/s41392-020-00305-5.

A new player in the beneficial effects of exercise on the aged brain

M Llorens-Martín  1   2   3
Affiliations
Comment

A new player in the beneficial effects of exercise on the aged brain

M Llorens-Martín. Signal Transduct Target Ther. .
No abstract available

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Conflict of interest statement

The author declares no competing interest.

Figures

Fig. 1
Fig. 1
Model proposed by Horowitz et al. Physical exercise increases the expression of glycosylphosphatidylinositol (GPI)-specific phospholipase D1 (Gpld1) in the liver of aged mice, increases adult hippocampal neurogenesis (AHN) and improves cognition. The transfer of plasma from aged or mature exercised mice to aged sedentary counterparts mimics the beneficial effects of physical activity. The authors identify Gpld1 as a key molecule in mediating the effects of physical exercise on AHN and cognition in aged mice. BBB blood–brain barrier, Plg plasminogen, Vtn vitronectin
See this image and copyright information in PMC

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References

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