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Review
. 2020 Sep;22(9):1033-1041.
doi: 10.1038/s41556-020-0567-z. Epub 2020 Sep 3.

Cellular and molecular architecture of the intestinal stem cell niche

Neil McCarthy  1   2 , Judith Kraiczy  1   2 , Ramesh A Shivdasani  3   4
Affiliations
Review

Cellular and molecular architecture of the intestinal stem cell niche

Neil McCarthy et al. Nat Cell Biol. 2020 Sep.

Abstract

Intestinal stem and progenitor cells replicate and differentiate in distinct compartments, influenced by Wnt, BMP, and other subepithelial cues. The cellular sources of these signals were long obscure because intestinal mesenchyme was insufficiently characterised. In this Review, we discuss how recent mRNA profiles of mouse and human intestinal submucosa, coupled with fine-resolution microscopy and gene and cell disruptions, reveal a coherent picture of an organised tissue carrying cells with distinct molecular properties and functions.

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References

    1. Clevers, H. The intestinal crypt, a prototype stem cell compartment. Cell 154, 274–284 (2013). - PubMed
    1. Medema, J. P. & Vermeulen, L. Microenvironmental regulation of stem cells in intestinal homeostasis and cancer. Nature 474, 318–326 (2011). - PubMed
    1. Tauriello, D. V. F. & Batlle, E. Targeting the microenvironment in advanced colorectal cancer. Trends Cancer 2, 495–504 (2016). - PubMed
    1. Barker, N. et al. Crypt stem cells as the cells-of-origin of intestinal cancer. Nature 457, 608–611 (2009). - PubMed
    1. Kuhnert, F. et al. Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1. Proc. Natl Acad. Sci. USA 101, 266–271 (2004). - PubMed

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