Review

. 2020 Sep;22(9):1033-1041.

doi: 10.1038/s41556-020-0567-z. Epub 2020 Sep 3.

Cellular and molecular architecture of the intestinal stem cell niche

Neil McCarthy^{1

2}, Judith Kraiczy^{1

2}, Ramesh A Shivdasani^{3

4}

Affiliations

¹ Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
² Department of Medicine, Harvard Medical School, Boston, MA, USA.
³ Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. ramesh_shivdasani@dfci.harvard.edu.
⁴ Department of Medicine, Harvard Medical School, Boston, MA, USA. ramesh_shivdasani@dfci.harvard.edu.

PMID: 32884148
DOI: 10.1038/s41556-020-0567-z

Review

Cellular and molecular architecture of the intestinal stem cell niche

Neil McCarthy et al. Nat Cell Biol. 2020 Sep.

. 2020 Sep;22(9):1033-1041.

doi: 10.1038/s41556-020-0567-z. Epub 2020 Sep 3.

Authors

Neil McCarthy^{1

2}, Judith Kraiczy^{1

2}, Ramesh A Shivdasani^{3

4}

Affiliations

¹ Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
² Department of Medicine, Harvard Medical School, Boston, MA, USA.
³ Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. ramesh_shivdasani@dfci.harvard.edu.
⁴ Department of Medicine, Harvard Medical School, Boston, MA, USA. ramesh_shivdasani@dfci.harvard.edu.

PMID: 32884148
DOI: 10.1038/s41556-020-0567-z

Abstract

Intestinal stem and progenitor cells replicate and differentiate in distinct compartments, influenced by Wnt, BMP, and other subepithelial cues. The cellular sources of these signals were long obscure because intestinal mesenchyme was insufficiently characterised. In this Review, we discuss how recent mRNA profiles of mouse and human intestinal submucosa, coupled with fine-resolution microscopy and gene and cell disruptions, reveal a coherent picture of an organised tissue carrying cells with distinct molecular properties and functions.

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Cellular and molecular architecture of the intestinal stem cell niche

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