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Review
. 2020 Aug 12:13:8037-8047.
doi: 10.2147/OTT.S264312. eCollection 2020.

Cervical Cancer: Emerging Immune Landscape and Treatment

Luopei Guo  1 , Keqin Hua  1   2
Affiliations
Review

Cervical Cancer: Emerging Immune Landscape and Treatment

Luopei Guo et al. Onco Targets Ther. .

Abstract

Immune cells are essential for defending the body's balance and have increasingly been implicated in controlling tumor growth. In cervical cancer (CC), the immune landscape is extensively connected with human papillomavirus (HPV) status. Recent insights from studies have revealed that as a result of infection with HPV, immune cell populations such as lymphocytes or monocytes change during carcinogenesis. Immune therapy, in particular checkpoint inhibitors, those targeting PD-1 or PD-L1, has shown promising efficacy. This article reviews the immune landscape and immunotherapy of CC.

Keywords: TIL; checkpoint blockade; immune; immune therapy; macrophage.

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Conflict of interest statement

The authors report no conflicts of interest for this work. This project was supported by funding from the Research and Innovation Project of Shanghai Municipal Education Commission (No. 2019-01-07-00-07-E00050), and the Shanghai Science and Technology Natural Science Foundation (No. 19ZR1406900).

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