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Clinical Trial
. 2020 Aug 20:2020:4747965.
doi: 10.1155/2020/4747965. eCollection 2020.

Hepatitis B Infection and Mother-to-Child Transmission in Haiphong, Vietnam: A Cohort Study with Implications for Interventions

Pham Minh Khue  1 , Nguyen Thi Thuy Linh  1 , Vu Hai Vinh  2 , Luu Vu Dung  3 , Bang Nguyen Van  4
Affiliations
Clinical Trial

Hepatitis B Infection and Mother-to-Child Transmission in Haiphong, Vietnam: A Cohort Study with Implications for Interventions

Pham Minh Khue et al. Biomed Res Int. .

Abstract

Background: There is little data available on HBV infection and mother-to-child transmission (MTCT) in Vietnam.

Objective: This study is aimed at assessing the prevalence of HBV infection and the current situation of MTCT in Haiphong, Vietnam.

Methods: A transversal survey of 1721 pregnant women followed by an observational prospective cohort study of 183 HBV-infected women was conducted at Haiphong Gyneco-Obstetric Hospital. Women were followed up up to 12-month postpartum; use of prevention measures and the MTCT rate were evaluated. HBV infection in children was defined by a HBsAg-positive test at 12 months of age.

Results: At baseline, 183 of 1721 pregnant women (10.6%) tested HBsAg positive. Among them, 23.0% were HBeAg positive, 26.2% had a detectable load of HBV DNA, and 13.1% had a HBV DNA load ≥ 200,000 IU/mL. All women underwent MTCT prevention antiviral therapy. At delivery, 98.9% of newborns receive a HBV vaccine birth dose, and 82% received HBIG. At 12 months of age, 94.7% have received the scheduled HBV vaccines. Eight percent of infants born from followed-up women were HBsAg positive. The mother's HBeAg-positive status was associated with a higher risk of HBV infection in infants.

Conclusion: The HBV prevalence and MTCT rates are high in Haiphong. A strong national plan to increase the access to preventive measures and to monitor results is needed in order to decrease this prevalence.

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Conflict of interest statement

The authors have no conflict of interest to report.

Figures

Figure 1
Figure 1
Participant enrollment and follow-up.
See this image and copyright information in PMC

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