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. 2020 Aug 10;4(4):e453.
doi: 10.1097/HS9.0000000000000453. eCollection 2020 Aug.

Clonal Hematopoiesis in Hospitalized Elderly Patients With COVID-19

Erik Hameister  1 , Sebastian M Stolz  1 , Yvonne Fuhrer  1 , Friedrich Thienemann  2 , Dominik J Schaer  2 , Johannes Nemeth  3 , Reto A Schuepbach  4 , Jeroen Goede  5 , Sophie Reinhart  5 , Adrian Schmidt  6 , Abdullah Kahraman  7 , Mathias Schmid  6 , Holger Moch  7 , Martin Zoche  7 , Markus G Manz  1 , Stefan Balabanov  1 , Steffen Boettcher  1
Affiliations

Clonal Hematopoiesis in Hospitalized Elderly Patients With COVID-19

Erik Hameister et al. Hemasphere. .
No abstract available

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Conflict of interest statement

The authors have indicated they have no potential conflicts of interest to disclose.

Figures

Figure 1
Figure 1
Clonal hematopoiesis in elderly patients with COVID-19. (A) Mutational landscape of somatic mutations detected in elderly patients with moderate or severe COVID-19, or in a matched control group of patients without COVID-19. (B) Number of patients with moderate or severe COVID-19 or control patients with ≥1 mutation. (C) Variant allele frequencies (VAFs) in the matched control group, and in patients with moderate or severe COVID-19, respectively. Statistical significance was calculated using the Mann-Whitney test. (D) Proportion of patients affected by CH in the control group, and in patients with moderate or severe COVID-19. (E) Age of patients affected by CH in the control group, and in patients with moderate or severe COVID-19. Mann-Whitney test was used to calculate statistical significance. (F) Odds ratios for the association between CH and the development of severe COVID-19 further stratified according to a variant allele frequencies (VAF) of <0.1 or ≥0.1 (statistical significance was calculated using Fisher exact test).
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