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. 2021 Jan;29(1):29-37.
doi: 10.1002/oby.23029. Epub 2020 Dec 6.

Independent Role of Severe Obesity as a Risk Factor for COVID-19 Hospitalization: A Spanish Population-Based Cohort Study

Ujué Fresán  1   2   3 , Marcela Guevara  1   2   3 , Fernando Elía  3   4 , Esther Albéniz  3   4 , Cristina Burgui  1   2   3 , Jesús Castilla  1   2   3 ; Working Group for the Study of COVID-19 in Navarra
Collaborators, Affiliations

Independent Role of Severe Obesity as a Risk Factor for COVID-19 Hospitalization: A Spanish Population-Based Cohort Study

Ujué Fresán et al. Obesity (Silver Spring). 2021 Jan.

Abstract

Objectives: This study analyzed the association between severe obesity and coronavirus disease 2019 (COVID-19) hospitalization and severe disease.

Methods: The incidence of hospitalization for laboratory-confirmed COVID-19 was evaluated in a prospective population-based cohort of 433,995 persons aged 25 to 79 years in Spain during March and April of 2020. Persons with and without class 3 obesity were compared using Poisson regression to estimate the adjusted relative risk (aRR) from class 3 obesity of COVID-19 hospitalization and of severe disease (intensive care unit admission or death). Differences in the effect by age, sex, and chronic conditions were evaluated.

Results: Individuals with class 3 obesity had a higher risk of hospitalization (aRR = 2.20, 95% CI: 1.66-2.93) and developing severe COVID-19 (aRR = 2.30, 95% CI: 1.20-4.40). In people younger than 50 years, these effects were more pronounced (aRR = 5.02, 95% CI: 3.19-7.90 and aRR = 13.80, 95% CI: 3.11-61.17, respectively), whereas no significant effects were observed in those aged 65 to 79 years (aRR = 1.22, 95% CI: 0.70-2.12 and aRR = 1.42, 95% CI: 0.52-3.88, respectively). Sex and chronic conditions did not modify the effect of class 3 obesity in any of the outcomes.

Conclusions: Severe obesity is a relevant risk factor for COVID-19 hospitalization and severity in young adults, having a magnitude similar to that of aging. Tackling the current obesity pandemic could alleviate the impact of chronic and infectious diseases.

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References

    1. Coronavirus Resource Center. Johns Hopkins University & Medicine. Accessed May 6, 2020. https://coronavirus.jhu.edu/
    1. World Health Organization. WHO characterizes COVID-19 as a pandemic. Published March 11, 2020. Accessed May 6, 2020. https://www.who.int/emergencies/diseases/novel-coronavirus-2019/events-a...
    1. Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 2020;395:1054-1062.
    1. Wu C, Chen X, Cai Y, et al. Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China. JAMA Intern Med 2020:180:934-943. doi:10.1001/jamainternmed.2020.0994
    1. Hu L, Chen S, Fu Y, et al. Risk factors associated with clinical outcomes in 323 coronavirus disease 2019 (COVID-19) hospitalized patients in Wuhan, China. Clin Infect Dis 2020:71:2089-2098. doi:10.1093/cid/ciaa539

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