Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Sep 2;12(9):2673.
doi: 10.3390/nu12092673.

Dietary Oxalate Intake and Kidney Outcomes

Matteo Bargagli  1   2 , Maria Clarissa Tio  3 , Sushrut S Waikar  4 , Pietro Manuel Ferraro  1   2
Affiliations
Review

Dietary Oxalate Intake and Kidney Outcomes

Matteo Bargagli et al. Nutrients. .

Abstract

Oxalate is both a plant-derived molecule and a terminal toxic metabolite with no known physiological function in humans. It is predominantly eliminated by the kidneys through glomerular filtration and tubular secretion. Regardless of the cause, the increased load of dietary oxalate presented to the kidneys has been linked to different kidney-related conditions and injuries, including calcium oxalate nephrolithiasis, acute and chronic kidney disease. In this paper, we review the current literature on the association between dietary oxalate intake and kidney outcomes.

Keywords: acute kidney injury; chronic kidney disease; diet; nephrocalcinosis; nephrolithiasis; oxalate.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

References

    1. Holmes R.P., Goodman H.O., Assimos D.G. Contribution of dietary oxalate to urinary oxalate excretion. Kidney Int. 2001;59:270–276. doi: 10.1046/j.1523-1755.2001.00488.x. - DOI - PubMed
    1. Coe F.L., Evan A., Worcester E. Kidney stone disease. J. Clin. Investig. 2005;115:2598–2608. doi: 10.1172/JCI26662. - DOI - PMC - PubMed
    1. Hatch M., Freel R.W., Vaziri N.D. Intestinal excretion of oxalate in chronic renal failure. J. Am. Soc. Nephrol. 1994;5:1339–1343. - PubMed
    1. Costello J.F., Smith M., Stolarski C., Sadovnic M.J. Extrarenal clearance of oxalate increases with progression of renal failure in the rat. J. Am. Soc. Nephrol. 1992;3:1098–1104. - PubMed
    1. Hatch M., Freel R.W. Angiotensin II involvement in adaptive enteric oxalate excretion in rats with chronic renal failure induced by hyperoxaluria. Urol. Res. 2003;31:426–432. doi: 10.1007/s00240-003-0367-5. - DOI - PubMed

Supplementary concepts