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Review
. 2020 Sep 2;12(9):2487.
doi: 10.3390/cancers12092487.

Patient-Reported Outcome Measures in Pancreatic Cancer Receiving Radiotherapy

Ramez Kouzy  1   2 , Joseph Abi Jaoude  1   2 , Daniel Lin  1   2 , Nicholas D Nguyen  1   2 , Molly B El Alam  1   2 , Ethan B Ludmir  1 , Cullen M Taniguchi  1   2
Affiliations
Review

Patient-Reported Outcome Measures in Pancreatic Cancer Receiving Radiotherapy

Ramez Kouzy et al. Cancers (Basel). .

Abstract

Pancreatic cancer and its treatment often dramatically impact patients' quality of life (QoL). Given this, as well as increased focus on QoL measures in clinical oncology, there has been a rise in the number of instruments that measure patient-reported outcomes (PROs). In this review, we describe the landscape of different PRO instruments pertaining to pancreatic cancer, with specific emphasis on PRO findings related to pancreatic cancer patients receiving radiotherapy (RT). Twenty-five of the most commonly utilized PROs are compared in detail. Notably, most of the PRO tools discussed are not specific to pancreatic cancer but are generic and have been used in various malignancies. Published findings concerning PROs in pancreatic cancer involving RT are also extracted and summarized. Among the measures used, the European Organization for Research and Treatment Cancer QLQ-C30 was the most commonly utilized. We recommend a careful selection of PRO measures in clinical pancreatic cancer research and care and encourage the use of a combination of symptom-specific and global QoL tools to more fully capture patients' perspectives.

Keywords: pancreatic cancer; patient reported outcomes; quality of life; radiotherapy.

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Conflict of interest statement

C.M.T. is supported by funding from the NIH under award R01CA227517-01A1, Cancer Prevention & Research Institute of Texas (CPRIT) grant RR140012, V Foundation (V2015-22), the Kimmel Foundation, Sabin Family Foundation Fellowship, Reaumond Family Foundation, Childress Institute Funds, and the McNair Foundation.

Figures

Figure 1
Figure 1
Patient-reported outcome (PRO) measure selection algorithm.
See this image and copyright information in PMC

References

    1. Schnipper L.E., Davidson N.E., Wollins D.S., Blayney D.W., Dicker A.P., Ganz P.A., Hoverman J.R., Langdon R., Lyman G.H., Meropol N.J., et al. Updating the American Society of Clinical Oncology Value Framework: Revisions and Reflections in Response to Comments Received. J. Clin. Oncol. 2016;34:2925–2934. doi: 10.1200/JCO.2016.68.2518. - DOI - PubMed
    1. Cherny N.I., Sullivan R., Dafni U., Kerst J.M., Sobrero A., Zielinski C., de Vries E.G.E., Piccart M.J. A standardised, generic, validated approach to stratify the magnitude of clinical benefit that can be anticipated from anti-cancer therapies: The European Society for Medical Oncology Magnitude of Clinical Benefit Scale (ESMO-MCBS) Ann. Oncol. 2015;26:1547–1573. doi: 10.1093/annonc/mdv249. - DOI - PubMed
    1. Levit L.A., Balogh E.P., Nass S.J., Ganz P.A. Committee on Improving the Quality of Cancer Care: Addressing the Challenges of an Aging Population. National Academies Press; Washington, DC, USA: 2013. p. 413. - PubMed
    1. Basch E., Deal A.M., Dueck A.C., Scher H.I., Kris M.G., Hudis C., Schrag D. Overall Survival Results of a Trial Assessing Patient-Reported Outcomes for Symptom Monitoring During Routine Cancer Treatment. JAMA. 2017;318:197–198. doi: 10.1001/jama.2017.7156. - DOI - PMC - PubMed
    1. Patrick D.L., Burke L.B., Powers J.H., Scott J.A., Rock E.P., Dawisha S., O’Neill R., Kennedy D.L. Patient-Reported Outcomes to Support Medical Product Labeling Claims: FDA Perspective. Value Health. 2007;10:S125–S137. doi: 10.1111/j.1524-4733.2007.00275.x. - DOI - PubMed

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