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Comment
. 2020 Nov;17(11):653-654.
doi: 10.1038/s41575-020-00363-8.

Determining the reliability of liver biopsies in NASH clinical studies

Thomas Longerich  1 , Peter Schirmacher  2
Affiliations
Comment

Determining the reliability of liver biopsies in NASH clinical studies

Thomas Longerich et al. Nat Rev Gastroenterol Hepatol. 2020 Nov.
No abstract available

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References

    1. Harrison, S. A. et al. Insulin sensitizer MSDC-0602K in non-alcoholic steatohepatitis: a randomized, double-blind, placebo-controlled phase IIb study. J. Hepatol. 72, 613–626 (2020). - DOI
    1. Davison, B. A. et al. Suboptimal reliability of liver biopsy evaluation has implications for randomized clinical trials. J. Hepatol. https://doi.org/10.1016/j.jhep.2020.06.025 (2020). - DOI - PubMed
    1. Kleiner, D. E. et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 41, 1313–1321 (2005). - DOI
    1. The French METAVIR Cooperative Study Group. Intraobserver and interobserver variations in liver biopsy interpretation in patients with chronic hepatitis C. Hepatology 20, 15–20 (1994). - DOI
    1. Bedossa, P. et al. Histopathological algorithm and scoring system for evaluation of liver lesions in morbidly obese patients. Hepatology 56, 1751–1759 (2012). - DOI

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