Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2020 Sep 1;25(11):1894-1896.
doi: 10.1016/j.drudis.2020.08.007. Online ahead of print.

Could PROTACs Protect Us From COVID-19?

Wilnelly Martinez-Ortiz  1 , Ming-Ming Zhou  2
Affiliations
Editorial

Could PROTACs Protect Us From COVID-19?

Wilnelly Martinez-Ortiz et al. Drug Discov Today. .
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Graphical illustration, via molecular structure superimposition, of the mechanism of action of a putative antiviral PROTAC targeting SARS-COV-2 protein E. (a) SARS-COV-2 (illustration adapted from CDC) highlighing small envelope protein E (green, PDB:5 × 29 pentamer; PDB:2MM4 monomer) as a selected target for PROTAC. (b) Engagement of a putative PROTAC (royal blue) in a ternary complex with protein E (green) and the targeted E3 ligase (black, PDB:6HAY). (c) The viral protein E (green) degradation is promoted by the poteosome (gray, PDB:6MSB), and results in the MHC-I presentation of viral epitopes (light gray, PDB:5OQF) to host immune CD8+ T-cells. (d) Immune response and generation of antiviral antibody (light blue, PDB:4PY8) against SARS-COV-2 protein E in COVID-19.
See this image and copyright information in PMC

References

    1. Lai A.C., Crews C.M. Induced protein degradation: an emerging drug discovery paradigm. Nat. Rev. Drug Discov. 2017;16(2):101–114. - PMC - PubMed
    1. Wang Z. Proteolysis Targeting chimeras for the selective degradation of Mcl-1/Bcl-2 derived from nonselective target binding ligands. J. Med. Chem. 2019;62(17):8152–8163. - PubMed
    1. Bondeson D.P. Lessons in PROTAC Design from Selective Degradation with a Promiscuous Warhead. Cell Chem. Biol. 2018;25(1):78–87.e75. - PMC - PubMed
    1. Jensen S.M. Specific MHC-I Peptides Are Induced Using PROTACs. Front Immunol. 2018;9:2697. - PMC - PubMed
    1. Gadd M.S. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat. Chem. Biol. 2017;13(5):514–521. - PMC - PubMed

Publication types

LinkOut - more resources