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Observational Study
. 2021 Jan;9(1):527-530.e1.
doi: 10.1016/j.jaip.2020.08.041. Epub 2020 Sep 2.

Limited effect of intramuscular epinephrine on cardiovascular parameters during peanut-induced anaphylaxis: An observational cohort study

Paul J Turner  1 , Monica Ruiz-Garcia  2 , Stephen R Durham  3 , Robert J Boyle  2
Affiliations
Observational Study

Limited effect of intramuscular epinephrine on cardiovascular parameters during peanut-induced anaphylaxis: An observational cohort study

Paul J Turner et al. J Allergy Clin Immunol Pract. 2021 Jan.
No abstract available

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Figures

Figure 1
Figure 1
Changes in cardiovascular parameters at the time of objective clinical reaction (OCR) during peanut-induced anaphylaxis and after intramuscular (IM) epinephrine injection (at T = 0). Data are means with 95% CI, n = 14. ∗P < .05, ∗∗P < .01, ∗∗∗∗P < .0001, t-test. CI, Confidence interval; CO, cardiac output; HR, heart rate; MAP, mean arterial pressure; SV, stroke volume.
Figure 2
Figure 2
Changes in cardiovascular parameters at objective clinical reaction (OCR) with (in red) or without (in blue) IM epinephrine treatment (at T = 0), during peanut-induced anaphylaxis in participants who experienced anaphylaxis on more than 1 occasion, where only 1 reaction was treated with epinephrine. Data are means with 95% CI, n = 8. ∗P < .05, ∗∗P < .01, paired t-test. CI, Confidence interval; CO, cardiac output; HR, heart rate; IM, intramuscular; SV, stroke volume.
Figure E1
Figure E1
Change in heart rate (HR) and stroke volume (SV) in 2 participants who received 2 doses of IM epinephrine. IM, Intramuscular; OCR, objective clinical reaction.
See this image and copyright information in PMC

References

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