Modulation of telomerase expression and function by miRNAs: Anti-cancer potential

Affiliations

¹ Department of Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran; Department of Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.
² Solid Tumor Research Center, Urmia University of Medical Sciences, Urmia, Iran.
³ Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.
⁴ Department of Orthopedic Surgery, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
⁵ Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
⁶ Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Clinical Biochemistry, Tabriz University of Medical Sciences, Tabriz, Iran.
⁷ Students Research Committee, Babol University of Medical Sciences, Babol, Iran; Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
⁸ Students Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
⁹ Department of Clinical Biochemistry, Tabriz University of Medical Sciences, Tabriz, Iran.
¹⁰ Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran; Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
¹¹ Department of Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran. Electronic address: naderfarsad@yahoo.com.
¹² Institute of Research and Development, Duy Tan University, Da Nang, Viet Nam; Department of Immunology, Ophthalmology and ENT, School of Medicine, Complutense University, Madrid, Spain. Electronic address: aminsafa@ucm.es.
¹³ Molecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: yousefib@tbzmed.ac.ir.

PMID: 32890603
DOI: 10.1016/j.lfs.2020.118387

Review

Modulation of telomerase expression and function by miRNAs: Anti-cancer potential

Aysan Salamati et al. Life Sci. 2020.

. 2020 Oct 15:259:118387.

doi: 10.1016/j.lfs.2020.118387. Epub 2020 Sep 3.

Authors

Affiliations

¹ Department of Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran; Department of Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.
² Solid Tumor Research Center, Urmia University of Medical Sciences, Urmia, Iran.
³ Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.
⁴ Department of Orthopedic Surgery, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
⁵ Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
⁶ Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Clinical Biochemistry, Tabriz University of Medical Sciences, Tabriz, Iran.
⁷ Students Research Committee, Babol University of Medical Sciences, Babol, Iran; Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
⁸ Students Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
⁹ Department of Clinical Biochemistry, Tabriz University of Medical Sciences, Tabriz, Iran.
¹⁰ Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran; Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
¹¹ Department of Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran. Electronic address: naderfarsad@yahoo.com.
¹² Institute of Research and Development, Duy Tan University, Da Nang, Viet Nam; Department of Immunology, Ophthalmology and ENT, School of Medicine, Complutense University, Madrid, Spain. Electronic address: aminsafa@ucm.es.
¹³ Molecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: yousefib@tbzmed.ac.ir.

PMID: 32890603
DOI: 10.1016/j.lfs.2020.118387

Abstract

Telomerase is a nucleoprotein reverse transcriptase that maintains the telomere, a protective structure at the ends of the chromosome, and is active in cancer cells, stem cells, and fetal cells. Telomerase immortalizes cancer cells and induces unlimited cell division by preventing telomere shortening. Immortalized cancer cells have unlimited proliferative potential due to telomerase activity that causes tumorigenesis and malignancy. Therefore, telomerase can be a lucrative anti-cancer target. The regulation of catalytic subunit of telomerase (TERT) determines the extent of telomerase activity. miRNAs, as an endogenous regulator of gene expression, can control telomerase activity by targeting TERT mRNA. miRNAs that have a decreasing effect on TERT translation mediate modulation of telomerase activity in cancer cells by binding to TERT mRNA and regulating TERT translation. In this review, we provide an update on miRNAs that influence telomerase activity by regulation of TERT translation.

Keywords: Anti-cancer; Telomerase; miRNAs.

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Modulation of telomerase expression and function by miRNAs: Anti-cancer potential

Affiliations

Modulation of telomerase expression and function by miRNAs: Anti-cancer potential

Authors

Affiliations

Abstract

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Medical