Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Nov 1:134:153-155.
doi: 10.1016/j.amjcard.2020.08.004. Epub 2020 Aug 12.

Meta-analysis of Effect of Statins in Patients with COVID-19

Affiliations
Review

Meta-analysis of Effect of Statins in Patients with COVID-19

Chia Siang Kow et al. Am J Cardiol. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

Declaration of interests The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Figure 1:
Figure 1
Pooled mortality and/or disease severity risk in COVID-19 patients using or not using statins. (Heterogeneity: I2=71%; p = 0.01)

Comment in

  • Statin Treatment of COVID-19.
    Fedson DS. Fedson DS. Am J Cardiol. 2020 Dec 1;136:171-173. doi: 10.1016/j.amjcard.2020.09.050. Epub 2020 Sep 28. Am J Cardiol. 2020. PMID: 32991850 Free PMC article. No abstract available.
  • More Good News on Statins and COVID-19.
    Katsiki N, Banach M, Mikhailidis DP. Katsiki N, et al. Am J Cardiol. 2021 Jan 1;138:127-128. doi: 10.1016/j.amjcard.2020.10.026. Epub 2020 Oct 23. Am J Cardiol. 2021. PMID: 33164793 Free PMC article. No abstract available.

References

    1. Yuan S. Statins May Decrease the Fatality Rate of Middle East Respiratory Syndrome Infection. mBio. 2015;6:e01120. - PMC - PubMed
    1. Yuan X, Deng Y, Guo X, Shang J, Zhu D, Liu H. Atorvastatin attenuates myocardial remodeling induced by chronic intermittent hypoxia in rats: partly involvement of TLR-4/MYD88 pathway. Biochem Biophys Res Commun. 2014;446(1):292–297. - PubMed
    1. Totura AL, Whitmore A, Agnihothram S. Toll-Like Receptor 3 Signaling via TRIF Contributes to a Protective Innate Immune Response to Severe Acute Respiratory Syndrome Coronavirus Infection. mBio. 2015;6(3) e00638-15. - PMC - PubMed
    1. Li YH, Wang QX, Zhou JW. Effects of rosuvastatin on expression of angiotensin-converting enzyme 2 after vascular balloon injury in rats. J Geriatr Cardiol. 2013;10(2):151–158. - PMC - PubMed
    1. Shresta S. Statin drug therapy may increase COVID-19 infection. Nepal Med J. 2020;5(3)

Substances