Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Feb;15(1):24-27.
doi: 10.1016/j.pcd.2020.08.015. Epub 2020 Aug 29.

Diabetes and COVID-19: A pooled analysis related to disease severity and mortality

Seshadri Reddy Varikasuvu  1 , Naveen Dutt  2 , Balachandar Thangappazham  3 , Saurabh Varshney  4
Affiliations
Review

Diabetes and COVID-19: A pooled analysis related to disease severity and mortality

Seshadri Reddy Varikasuvu et al. Prim Care Diabetes. 2021 Feb.

Abstract

Globally, COVID-19 has become a major concern for the diabetic community. We conducted a pooled analysis and constructed a forest plot for the association between diabetes and COVID-19 progression in 47 studies. A random effects meta-analysis (Mantel-Haenszel method) was conducted to estimate the outcomes effect size as odds ratios (OR) and 95% confidence intervals (CI) using Review Manager Software version 5.3. COVID-19 patients with diabetes have a significantly higher risk of disease severity (OR=2.20, 95% CI=1.69-2.86, p<0.00001) and associated mortality outcomes (OR=2.52, 95% CI=1.93-3.30, p=<0.00001).

Keywords: COVID-19; Comorbidities; Diabetes.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Forest plot relating diabetes to disease severity and survival in COVID-19 patients from 47 studies.
Fig. 2
Fig. 2
The funnel plot of studies included in the analysis.
See this image and copyright information in PMC

References

    1. Beran D., Aebischer Perone S., Castellsague Perolini M. Beyond the virus: ensuring continuity of care for people with diabetes during COVID-19. Prim. Care Diabetes. 2020 doi: 10.1016/j.pcd.2020.05.014. S1751-9918(20)30199-6 [published online ahead of print, 2020 May 30] - DOI - PMC - PubMed
    1. Wang W., Lu J., Gu W., Zhang Y., Liu J., Ning G. Care for diabetes with COVID-19: advice from China. J. Diabetes. 2020;12(5):417–419. doi: 10.1111/1753-0407.13036. - DOI - PubMed
    1. Bornstein S.R., Rubino F., Khunti K. Practical recommendations for the management of diabetes in patients with COVID-19. Lancet Diabetes Endocrinol. 2020;8(6):546–550. doi: 10.1016/S2213-8587(20)30152-2. - DOI - PMC - PubMed
    1. Auld Sara C., Caridi-Scheible M., Blum James M., Robichaux C., Kraft C., Jacob Jesse T. ICU and ventilator mortality among critically ill adults with coronavirus disease. Crit Care Med 2019. 2020:1–6. doi: 10.1097/CCM.0000000000004457. - DOI - PMC - PubMed
    1. Guang C., Di W., Wei G., Yong C., Da H., Hongwu W. Clinical and immunological features of severe and moderate coronavirus disease 2019. J. Clin. Invest. 2020;130(5):2620–2629. doi: 10.1172/JCI137244. - DOI - PMC - PubMed