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Comment
. 2020 Oct;26(10):889-890.
doi: 10.1016/j.molmed.2020.08.004. Epub 2020 Sep 4.

Huntington's Disease: Les Jeux Sont Faits?

Edith L Pfister  1 , Neil Aronin  2
Affiliations
Comment

Huntington's Disease: Les Jeux Sont Faits?

Edith L Pfister et al. Trends Mol Med. 2020 Oct.

Abstract

In a meticulous study, Humbert, Durr, and colleagues showed evidence for aberrant neurodevelopment in both Huntington's disease (HD) and mouse models of HD. We consider the implications of prenatal pathological changes for the onset and progression of HD and their relatedness to current therapeutic plans.

Keywords: Huntington’s disease; neurodevelopment.

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  • Huntington's disease alters human neurodevelopment.
    Barnat M, Capizzi M, Aparicio E, Boluda S, Wennagel D, Kacher R, Kassem R, Lenoir S, Agasse F, Braz BY, Liu JP, Ighil J, Tessier A, Zeitlin SO, Duyckaerts C, Dommergues M, Durr A, Humbert S. Barnat M, et al. Science. 2020 Aug 14;369(6505):787-793. doi: 10.1126/science.aax3338. Epub 2020 Jul 16. Science. 2020. PMID: 32675289 Free PMC article.

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