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Comparative Study
. 2020 Jul;493(1):181-184.
doi: 10.1134/S1607672920040043. Epub 2020 Sep 7.

Comparative Analysis of Long Noncoding RNA Expression in Human Hepatocyte Cell Lines and Liver

O Y Burenina  1 , T S Zatsepin  2   3 , E F Kim  4 , A V Metelin  4 , D A Skvortsov  3   5 , M P Rubtsova  2   3 , O A Dontsova  2   3
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Comparative Study

Comparative Analysis of Long Noncoding RNA Expression in Human Hepatocyte Cell Lines and Liver

O Y Burenina et al. Dokl Biochem Biophys. 2020 Jul.

Abstract

Long noncoding RNAs (lncRNAs) are promising biomarkers and potential targets for liver cancer therapy. Stable hepatocyte lines are used in vitro to investigate functions of lncRNAs which amount in cell fluctuates during carcinogenesis. For the first time we compared gene expression of known lncRNAs in human conditional normal liver cells HepaRG and cancer cell lines Huh7 and HepG2. We showed that relative amounts of these lncRNAs in HepaRG are close to analogous variables measured for liver samples from healthy donors. Obtained data demonstrate exclusive peculiarities of HepaRG and confirm its reasonable application as a model of normal human hepatocytes for studying functions of lncRNAs.

Keywords: HepaRG; liver cancer; Кeywords: long noncoding RNAs.

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