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. 2020 Nov;80(15):1365-1372.
doi: 10.1002/pros.24067. Epub 2020 Sep 7.

Interactive effect of TLR SNPs and exposure to sexually transmitted infections on prostate cancer risk in Jamaican men

Bhawna Dubey  1 , Maria Jackson  2 , Charnita Zeigler-Johnson  3 , Karthik Devarajan  4 , Rafael E Flores-Obando  5 , Norma McFarlane-Anderson  6 , Marshall Tulloch-Reid  7 , William Aiken  8 , Kevin Kimbro  9 , Dominique Reed  10 , LaCreis R Kidd  10 , Denise Gibbs  1 , Sudhir Kumar  11 , Camille Ragin  1
Affiliations

Interactive effect of TLR SNPs and exposure to sexually transmitted infections on prostate cancer risk in Jamaican men

Bhawna Dubey et al. Prostate. 2020 Nov.

Abstract

Background: Prostate cancer (PC) risk increases with African ancestry and a history of sexually transmitted infections (STIs). Also, single-nucleotide polymorphisms (SNPs) in toll-like receptor (TLR) genes influence PC risk. This pilot study explores interactions between STIs and TLR-related SNPs in relation to PC risk among Jamaican men.

Methods: This case-control study evaluates two TLR related SNPs in 356 Jamaican men (194 controls and 162 cases) with or without history of STIs using stepwise penalized logistic regression in multivariable analyses.

Results: Age (odds ratio [OR] = 1.08; 95% confidence interval [CI]: 1.04-1>.12; p < .001) and IRF3_rs2304206 GG genotype (OR = 0.47; 95% CI: 0.29-0<.78; p = .003) modulated PC risk in people with history of STIs. In the population with no history of STIs, resulting interactions between risk factors did not survive correction for multiple hypothesis testing.

Conclusion: Overall, an interaction between the IFR3_rs2304206 variant and a history of exposure to STIs leads to greater decrease of PC risk than the presence of polymorphic genotype alone. These findings are suggestive and require further validation. Identification of gene variants along with detection of lifestyle behaviors may contribute to identification of men at a greater risk of PC development in the population.

Keywords: StepPLR; black; prostate cancer; sexually transmitted infections; single nucleotide polymorphisms; toll-like receptor (TLR).

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Conflict of interest statement

CONFLICT OF INTEREST: The authors declare no conflict of interest.

References

    1. Society AC. Cancer Facts & Figures 2019. American Cancer Society; 2019.
    1. Gann PH. Risk factors for prostate cancer. Rev Urol. 2002;4 Suppl 5:S3–S10. - PMC - PubMed
    1. Sarma AV, McLaughlin JC, Wallner LP, et al. Sexual behavior, sexually transmitted diseases and prostatitis: the risk of prostate cancer in black men. The Journal of urology. 2006;176(3):1108–1113. - PubMed
    1. Taylor ML, Mainous AG 3rd, Wells BJ. Prostate cancer and sexually transmitted diseases: a meta-analysis. Family medicine. 2005;37(7):506–512. - PubMed
    1. Coussens LM, Werb Z. Inflammation and cancer. Nature. 2002;420(6917):860–867. - PMC - PubMed

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