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Review
. 2021 May 25;60(22):12170-12191.
doi: 10.1002/anie.202009995. Epub 2021 Feb 8.

Radical-Promoted Distal C-H Functionalization of C(sp3 ) Centers with Fluorinated Moieties

Enzo Nobile  1 , Thomas Castanheiro  1 , Tatiana Besset  1
Affiliations
Review

Radical-Promoted Distal C-H Functionalization of C(sp3 ) Centers with Fluorinated Moieties

Enzo Nobile et al. Angew Chem Int Ed Engl. .

Abstract

Due to their unique properties, fluorinated scaffolds are pivotal compounds in pharmaceuticals, agrochemicals, and materials science. Over the last years, the development of versatile strategies for the selective synthesis of fluorinated molecules by direct C-H bond functionalization has attracted a lot of attention. In particular, the design of novel transformations based on a radical process was a bottleneck for distal C-H functionalization reactions, offering synthetic solutions for the selective introduction of fluorinated groups. This Minireview highlights the major contributions in this blossoming field. The development of new methodologies for the remote functionalization of aliphatic derivatives with various fluorinated groups based on a 1,5-hydrogen atom transfer process and a β-fragmentation reaction will be showcased and discussed.

Keywords: C(sp3) centers; C−H functionalization; fluorinated moieties; radical reactions; remote positions.

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