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Editorial
. 2020 Sep 8;142(10):963-966.
doi: 10.1161/CIRCULATIONAHA.120.049268. Epub 2020 Sep 8.

A Phosphatase Anchor Weighs on the Heart

Kathleen C Woulfe  1 , Joshua G Travers  1   2 , Timothy A McKinsey  1   2
Affiliations
Editorial

A Phosphatase Anchor Weighs on the Heart

Kathleen C Woulfe et al. Circulation. .
No abstract available

Keywords: Editorials; calcineurin; calcium signaling; hypertrophy.

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Figures

Figure 1.
Figure 1.. A model for regulation of cardiomyocyte hypertrophy by distinct pools of calcineurin.
A perinuclear pool of CaNAβ associated with mAKAPβ is stimulated by stress-induced Ca2+/calmodulin (CaM) signaling, resulting in activation of the pro-hypertrophic transcription factors nuclear factor of activated T cells (NFAT) and myocyte enhancer factor-2 (MEF2). Stimulation of a pool of CaNAβ that is anchored to the subsarcolemmal region of cardiomyocytes by CIP4 also triggers hypertrophy through dephosphorylation of substrates that remain unknown.
See this image and copyright information in PMC

Comment on

References

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