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. 2020 Sep 4;99(36):e22013.
doi: 10.1097/MD.0000000000022013.

Prevalence and risk factors for intensive care unit acquired weakness: A protocol for a systematic review and meta-analysis

Affiliations

Prevalence and risk factors for intensive care unit acquired weakness: A protocol for a systematic review and meta-analysis

Zheng Li et al. Medicine (Baltimore). .

Abstract

Background: Intensive care unit-acquired weakness (ICU-AW) is an acquired neuromuscular lesion and a common occurrence in patients who are critically ill. We will systematically summarize and incorporate the important risk factors and prevalence from previously published multivariate analyses for ICU-AW.

Methods: We will search the PubMed, Embase, Web of Science, and the Cochrane library to identify the relevant studies about the prevalence and risk factors for ICU-AW. Two reviewers will independently review the studies for eligibility according to the inclusion criteria. Two reviewers will independently assess the quality of studies by using the Newcastle-Ottawa scale for nonrandomized studies. Heterogeneity among studies will be estimated by the I statistic.

Results: This systematic review and meta-analysis will provide an evidence of prevalence and risk factors for the ICU-AW.

Conclusion: We hope that our research will contribute to clinicians and public decision making about the ICU-AW.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

References

    1. Stevens RD, Marshall SA, Cornblath DR, et al. A framework for diagnosing and classifying intensive care unit-acquired weakness. Crit Care Med 2009;37: 10 Suppl: S299–308.. - PubMed
    1. Latronico N, Herridge M, Hopkins RO, et al. The ICM research agenda on intensive care unit-acquired weakness. Intensive Care Med 2017;43:1270–81.. - PubMed
    1. Lacomis D, Zochodne DW, Bird SJ. Critical illness myopathy. Muscle Nerve 2000;23:1758–85.. - PubMed
    1. Latronico N, Bolton CF. Critical illness polyneuropathy and myopathy: a major cause of muscle weakness and paralysis. Lancet Neurol 2011;10:931–41.. - PubMed
    1. Fan E, Cheek F, Chlan L, et al. An official American Thoracic Society Clinical Practice guideline: the diagnosis of intensive care unit-acquired weakness in adults. Am J Respir Crit Care Med 2014;190:1437–46.. - PubMed