Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Sep 5;12(9):2719.
doi: 10.3390/nu12092719.

Age, Gender and Season Are Good Predictors of Vitamin D Status Independent of Body Mass Index in Office Workers in a Subtropical Region

Li-Kai Wang  1   2 , Kuo-Chuan Hung  1   2 , Yao-Tsung Lin  1   3 , Ying-Jen Chang  1   4 , Zhi-Fu Wu  1   5 , Chung-Han Ho  6 , Jen-Yin Chen  1   7
Affiliations

Age, Gender and Season Are Good Predictors of Vitamin D Status Independent of Body Mass Index in Office Workers in a Subtropical Region

Li-Kai Wang et al. Nutrients. .

Abstract

This study aimed at determining the prevalence and predictors of hypovitaminosis D (serum 25-hydroxyvitamin D < 30 ng/mL) among office workers in a subtropical region from an electronic hospital database. Totally, 2880 office workers aged 26-65 years who received health examinations with vitamin D status and total calcium concentrations at a tertiary referral center were retrospectively reviewed. Subjects were divided into groups according to genders, age (i.e., 26-35, 36-45, 46-55, 56-65), body-mass index (BMI) (i.e., obese BMI ≥ 30, overweight 25 ≤ BMI < 30, normal 20 ≤ BMI < 25, and underweight BMI < 20) and seasons (spring/winter vs. summer/autumn) for identifying the predictors of hypovitaminosis D. Corrected total calcium level <8.4 mg/dL is considered as hypocalcemia. Multivariate logistic regression demonstrated that females (AOR 2.33, (95% CI: 1.75, 3.09)), younger age (4.32 (2.98, 6.24), 2.82 (1.93, 4.12), 1.50 (1.03, 2.17)), and season (winter/spring) (1.55 (1.08, 2.22)) were predictors of hypovitaminosis D, whereas BMI was not in this study. Despite higher incidence of hypocalcemia in office workers with hypovitaminosis D (p < 0.001), there was no association between vitamin D status and corrected total calcium levels. A high prevalence (61.9%) of hypovitaminosis D among office workers in a subtropical region was found, highlighting the importance of this occupational health issue.

Keywords: age; gender; hypocalcemia; hypovitaminosis D; occupational health; season; subtropical.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Distribution of serum 25(OH)D concentrations among indoor workers. (a) Age-specific distributions of serum 25(OH)D concentrations in the total study population. (b) Age-specific distributions of serum 25(OH)D concentrations in males and females separately.
Figure 2
Figure 2
The receiver operating characteristic (ROC) curves for hypocalcemia to predict the incidence of hypovitaminosis D in Model 1. Adjusted for age, gender and season in Model 2. Adjusted for age, gender, season and phosphorus in Model 3. Adjusted for age, gender, season, phosphorus and estimated glomerular filtration rate (eGFR) in Model 4. The diagonal green line represents the line of no-discrimination.
See this image and copyright information in PMC

References

    1. Yang C.Y., Leung P.S., Adamopoulos I.E., Gershwin M.E. The implication of vitamin D and autoimmunity: A comprehensive review. Clin. Rev. Allergy Immunol. 2013;45:217–226. doi: 10.1007/s12016-013-8361-3. - DOI - PMC - PubMed
    1. Feng R., Li Y., Li G., Li Z., Zhang Y., Li Q., Sun C. Lower serum 25 (OH) D concentrations in type 1 diabetes: A meta-analysis. Diabetes Res. Clin. Pract. 2015;108:e71–e75. doi: 10.1016/j.diabres.2014.12.008. - DOI - PubMed
    1. Ju S.Y., Jeong H.S., Kim D.H. Blood vitamin D status and metabolic syndrome in the general adult population: A dose-response meta-analysis. J. Clin. Endocrinol. Metab. 2014;99:1053–1063. doi: 10.1210/jc.2013-3577. - DOI - PubMed
    1. Soderstrom L.H., Johnson S.P., Diaz V.A., Mainous A.G., 3rd Association between vitamin D and diabetic neuropathy in a nationally representative sample: Results from 2001–2004 NHANES. Diabet. Med. 2012;29:50–55. doi: 10.1111/j.1464-5491.2011.03379.x. - DOI - PMC - PubMed
    1. Chen J.Y., Lin Y.T., Wang L.K., Hung K.C., Lan K.M., Ho C.H., Chang C.Y. Hypovitaminosis din postherpetic neuralgia-high prevalence and inverse association with pain: A retrospective study. Nutrients. 2019;11:2787. doi: 10.3390/nu11112787. - DOI - PMC - PubMed

MeSH terms