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. 2020 Sep 4;9(9):2870.
doi: 10.3390/jcm9092870.

Anosmia and Ageusia as Predictive Signs of COVID-19 in Healthcare Workers in Italy: A Prospective Case-Control Study

Giuseppe La Torre  1 , Anna Paola Massetti  1   2 , Guido Antonelli  3 , Caterina Fimiani  1   2 , Mauro Fantini  1 , Mattia Marte  1 , Augusto Faticoni  1 , Carlo Maria Previte  1 , Ombretta Turriziani  3 , Francesco Pugliese  4 , Paolo Villari  1 , Ferdinando Romano  1 , Claudio Maria Mastroianni  1   2 , Covid-Sapienza Collaborative Group  5
Affiliations

Anosmia and Ageusia as Predictive Signs of COVID-19 in Healthcare Workers in Italy: A Prospective Case-Control Study

Giuseppe La Torre et al. J Clin Med. .

Abstract

Background: The aim of this study was to investigate the diagnostic accuracy of symptoms and signs in healthcare workers (HCW) with Sars-CoV-2.

Methods: This was a case-control study. Cases consisted of symptomatic healthcare workers who had a positive SARS-CoV-2 real-time polymerase chain reaction (RT-PCR) test, while controls were symptomatic healthcare workers with a negative RT-PCR test. For each symptom, ROCs were plotted. Diagnostic accuracy was calculated using the sensitivity, specificity, and positive and negative predictive values. A logistic regression analysis was carried out for calculating the OR (95% CI) for each symptom associated to the SARS-CoV-2 positivity.

Results: We recruited 30 cases and 75 controls. Fever had the best sensitivity while dyspnea, anosmia, and ageusia had the highest specificity. The highest PPVs were found again for dyspnea (75%), anosmia (73.7%), and ageusia (66.7%). Lastly, the highest NPVs were related to anosmia (81.4%) and ageusia (79.3%). Anosmia (OR = 14.75; 95% CI: 4.27-50.87), ageusia (OR = 9.18; 95% CI: 2.80-30.15), and headache (OR = 3.92; 95% CI: 1.45-10.56) are significantly associated to SARS-CoV-2 positivity.

Conclusions: Anosmia and ageusia should be considered in addition to the well-established fever, cough, and dyspnea. In a resource-limited setting, this method could save time and money.

Keywords: COVID-19; Italy; SARS-CoV-2; ageusia; anosmia; healthcare workers; signs; symptoms.

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Conflict of interest statement

The authors declare no conflict of interest.

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